CCT-1001: 3D texture synthesis and fitting CAD designers and CGI artists spend countless hours working with intricate 3D patterns. Our technology enables the generation of seemingly-random 3D patterns from sample geometry. These patterns and scaffolds are designed to merge seamlessly with existing patterned geometry. Possible uses include rapid prototyping (RP) of patterned objects such as bone implants, automatic mending of damaged models and stronger RP models using efficient supporting geometry. Read more...
CTT-0895: 3D vascularized pancreatic islets - for islets transplantation The present invention provides an advanced tissue-engineering technique for the development of 3D co-culture systems that reconstruct vascularization of pancreatic tissue ex vivo. In this novel engineered 3D pancreatic model, isolated pancreatic islets can be co-cultured with endothelial cells. The endothelial cells organize into 3D tubes throughout the engineered construct and form vascular network-like structures resembling in vivo vasculature. This presence of endothelial cells forming 3D vessel-like structures was found to be critical for islet survival. This model can provide an important tool for the therapeutic transplantation of islets, greatly increasing the success of the procedure. Read more...
DDL-1454: A new drug and gene delivery system to the brain Though the brain has relatively high blood flow, it remains one of the least accessible organs for drug delivery due to the blood-brain barrier (BBB) and cerebrospinal fluid barrier, which separate the brain from its blood supply and control the movement of compounds in and out of the brain. Our invention consists of nano-machines composed of liposomes that deliver pharmacological compounds through the BBB to specific sub-cellular targets in the brain, allowing efficient treatment of various neurodegenerative diseases and brain damage from brain trauma. Read more...
MED-1289: A non-invasive method for monitoring thermal tissue treatment Thermal treatments such as HIFU, RF and lasers for minimal invasive therapy and other clinical or cosmetic application have gradually become more and more prevalent. We suggest the use of CT which can be utilized for minimally or non-invasive image guided surgery instead of the expensive MRI. The suggested method may potentially monitor tissue temperature and amount of damage induced during thermal treatment in a non-invasive manner. Read more...
DRS-0972: A systems approach for understanding and controlling the reactivity of immune cell populations against cancer Tumor infiltrating lymphocytes (TILs) form immune populations with potential reactivity against melanoma. The degree of reactivity varies considerably among different TIL populations but the underlying network that governs the reactivity is poorly understood. The inventors were able to extract a simple set of subpopulation composition-based rules that explain reactivity to a large extent. Guided by the rules, they were able to restore anti-melanoma reactivity of nonreactive TILs by rational depletion and enrichment of selected subpopulations. This invention describes a generic approach for the prediction, understanding and control of a cell mixture function. Read more...
MAE-1038: Acoustic particle focusing This device enables acoustic focusing of micron and submicron particles in air. It can be used separately or in combination with aerodynamic lens arrays as an inlet to on-line single-particle analyzers including aerosol time-of-flight mass spectrometers, which are widely used in analytical chemistry, atmospheric dust analysis, biological detection, pharmaceutical manufacturing, and engine exhaust-gas analysis. The device allows for the supply of a concentrated (low gas volume, highly loaded) aerosol stream to on-line single-particle analyzers, allowing for a reduction in the required pumping power normally needed to sustain vacuum conditions. Read more...
STM-0890: Adult stem cell-derived connective tissue progenitors for tissue engineering The present invention provides methods for generating and utilization of connective tissue progenitor cells from adult stem cells, successfully overcoming shortcomings of presently known configurations. Adult stem cells differentiate into connective tissue progenitor cells capable of being maintained in a proliferative, non-terminally differentiated state for at least 20 passages in culture, and capable of differentiating into cells of chondrogenic lineage, osteogenic lineage, adipocytic lineage, tendon lineage and ligament lineage. The connective tissue progenitor cells are capable of forming extracellular matrix, mineralized matrix, bone tissue, cartilage tissue, tendon tissue and ligament tissue. Read more...
DRS-0655: An antibody fragment capable of modulating multidrug resistance The present invention relates to an antibody fragment capable of binding to
P-glycoprotein associated with multidrug resistant (MDR) cells. The present invention also relates to compositions and methods utilizing such an antibody fragment for inhibiting drug efflux activity in MDR cancer cells. Cancer chemotherapy often fails due to the development of acquired or intrinsic resistance in cancerous cells. A key mechanism of MDR is the overexpression of an energy-dependant efflux pump, known as the multidrug transporter. The present invention demonstrates an antibody that selectively reacts with Pgp-overexpressing cells and is, therefore, an effective inhibitor of drug-efflux activity in multi-drug resistant cells. Read more...
DRS-1315: Anticancer therapeutics via imidazoacridinone- and sunitinib-dependent lysosomal photodestruction Multidrug resistance (MDR) poses major obstacle for cancer treatment. Thus, developing novel strategies to overcome MDR is of a paramount clinical significance. The present invention proposes anticancer therapeutics and describes a new strategy to overcome MDR, based upon lysosomal sequestration of cytotoxic agents of the imidazoacridinones (IAs) family and consequent lysosomal photodestruction by illumination. Read more...
WAT-0526: Bacterial DNA fingerprint detection This is a fast and highly accurate system for identifying the presence of bacteria, based on the detection of its DNA sequence in the inspected medium. The technology is capable of identifying bacterial strains and can be easily adaptable to any bacteria. This new technology can be used to automatically detect the presence of bacteria in food and water, as well as in biological and medical samples. Read more...
DRS-0673: Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes Neomycin B is an important antibiotic, commonly used as a food-additive for agricultural purposes. As a result of antibiotic formulations having been used for several decades, resistance to antibiotics has been evolving. The present invention is a Neomycin B that has been modified by the addition of one extra sugar ring. This modification has been shown to both enhance its antibacterial activity against pathogenic bacterial strains and to produce a significant decline in bacterial resistance. The compounds are also active against Bacillus anthracis (anthrax) and are able to inhibit the proteolytic activity of its lethal factor. Read more...
MAE-1369: Bio-inspired control of legged locomotion enhanced using minimal feedback Current control methods for biped locomotion work mostly on horizontal planes, are relatively slow and non-human like. In order to be robust, these methods require large computation resources, as well as accurate sensors and actuators. The presented technology is a novel method that produces a more energy efficient walk over a wider range of slopes than available solutions. The invention is biologically inspired, thus, aside from contributing to the development of humanoid robots, it can help with robot assisted patient rehabilitation and walking platforms (exoskeletons), and with the improvement of orthotic devices. Read more...
COM-1158: Cancer diagnostic probe Effective diagnostics of cancerous cells during oncology surgeries is necessary for a successful treatment. Currently, treatments in these fields often result in repeated surgery which put the patient at risk and are costly. Therefore, providing the surgeon with a device which can accurately identify cancer can save repeated surgery and treatment costs while providing better healthcare. Our technology enables a breakthrough, low-cost and easy to operate device for ensuring the removal of all cancer cells during surgery. Read more...
DDL-1279: Cell-cell fusion method with application in specific delivery of anti-nematode agents using proteins from the FF family A new fusion method developed by Technion researchers depends on the expression of a certain glycoprotein of nematode origin in the membranes of both fusion partners. The new method for biological, protein mediated, cell to cell and virus to cell fusion can be used for targeting anthelmintics in a nematode specific manner. The homotypic character of the fusion may have many applications in the medical and research fields. Read more...
DDL-1161: Cell-derived liposomes for drug delivery A major challenge facing cancer therapy is achieving specific cytotoxic effect towards cancer cells while sparing the healthy ones. This invention describes the development of an innovative targeted system for cancer therapy based on Mesanchymal Stem Cell (MSC) derived liposomes. The engineered liposome may contain variety of anti-cancer or cytotoxin compounds which will be released directly into the cancer cells. Read more...
STM-1136: Co-derivation and expansion of vasculogenic pericytes and endothelial cells from hES cells and iPS Technion researchers have discovered a method for efficient, simple and inexpensive co-derivation of the two blood vessel cellular components: pericytes and endothelial cells, from a single pluripotent cell source. The robust expansion of mature vasculogenic cells, derived from pluripotent cells has the potential to achieve sufficient cell numbers for clinical transplantation. Read more...
DRS-1300: Combinations of corroles and statins High blood cholesterol levels and lipoprotein oxidation can lead to the formation of atherosclerotic lesions, which narrow the blood vessels and can lead to heart attack or stroke. We have created synthetic molecules, corroles, which are catalytic antioxidants and are more effective than current drugs for inhibiting cholesterol biosynthesis, making them extremely useful for treating diseases related to hypercholesterolemia. Read more...
CTT-1311: Composite biomaterials for cardiac tissue engineering Coronary heart disease (CHD) is a significant burden to healthcare systems as it is one of the leading causes of death in developed countries. In the present invention we propose an innovative strategy for treatment using a variety of injectable degradable composite biomaterials. This composite biomaterial promotes cell growth and may be used as cardiac patch for the regeneration of myocardial infarction and regeneration of other tissues/organs. Read more...
DDL-1074: Compositions and methods for drug delivery The present invention is of a hydrogel containing an immobilized, naturally-occurring protein drug carrier which may be used for sustained or controlled drug delivery applications. This hydrogel matrix can also be made to be biodegradable. Following this concept, a photopolymerizable hybrid hydrogel was developed, made of poly-ethylene-glycol conjugated to PEGylated albumin for affinity based drug delivery and tissue engineering applications. Read more...
DRS-0710: Compositions and methods for treating disorders associated with abnormal phosphate metabolism The present invention relates to methods for treating disorders associated with abnormal phosphate metabolism. Hyperphosphatemia has been associated with elevated mortality and morbidity among patients with chronic renal failure. The invention suggests assessing inducers of GalNAc-T3 as a new strategy for the treatment of hyperphosphatemia-related disorders such as renal failure, as well as assessing inhibitors of GalNAc-T3 for the treatment of disorders associated with hypophosphatemia, such as hypophosphatemic rickets. Read more...
DIA-0845: Concomitant analysis of salivary tumor markers - A new diagnostic tool for oral cancer The present invention relates to a method and diagnostic kit for diagnosing oral or oral-pharyngeal cancer using salivary testing. The novel method examines salivary tumor markers. A concurrent analysis of these markers showed sensitivity, specificity, and negative and positive predictive values in the range of 72-75%. Salivary testing is a non-invasive, effective and attractive alternative to serum testing. Read more...
DRS-1019: Corroles for chronic, systemic, and neurodegenerative diseases Treatment of neurodegenerative disorders, such as Huntington’s disease and amyotrophic lateral sclerosis (ALS), as well as disorders such as diabetes, has been frustrated by the shortcomings of the available symptomatic drugs. These drugs are incapable of slowing down the progression of the disease and neuronal degeneration. Ongoing research has clearly indicated that therapies aimed at blocking oxidative processes involving reactive oxygen species (ROS) and nitric oxide (NO) production may delay the progression of the disease. Metallocorroles designed in the invention have demonstrated remarkable antioxidant properties and have been proposed as an ingested medicine for the above stated conditions in addition to the previous work on atherosclerosis. Read more...
DRS-1457: Corroles for treatment of diseases of the eye Cataracts, the top cause of blindness worldwide, are especially prevalent in diabetic patients. The antioxidant supplements and cataract surgeries currently available lack efficiency for treatment of diabetic patients. We have developed new synthetic molecules that act as catalytic oxidants which can be used as oral or intravenous treatment for reducing the chances of developing cataracts, especially in diabetic patients. Read more...
MED-0939: Cylindrical probe for ex-situ nuclear magnetic resonance spectroscopy This invention is a new type of ex situ nuclear magnetic resonance (NMR) probe with spectroscopic capability. NMR, and its descendant, magnetic resonance imaging (MRI) are among the most powerful and versatile analytic and diagnostic methods in science. Current devices suffer from the need to employ large magnets that surround the examined sample/object. The large magnet and the correspondingly large RF coils are a major factor in the complexity and the high cost of NMR and MRI systems. In addition, in many cases the sample cannot be placed inside the bore of the magnet or cannot be moved. The present invention describes a new type of ex situ NMR probe, which through innovative design, achieves mobile NMR/MRI capability. The achievable spectral resolution is on the order of ~0.5-1 ppm. Read more...
MED-1303: Damaging cells using nanoparticles and short laser pulses Currently used anti-cancer treatments are highly toxic to both healthy and cancerous tissues, often leading to patient's death due to the treatment itself. We suggest novel strategy for the treatment of cancer by targeting cancer cells with carriers conjugated to gold nanospheres and illuminating the cells by short visible laser pulses. It will ensure local tissue damage whilst avoiding massive temperature elevation which may damage healthy tissues. Read more...
DRS-1049: Design, synthesis and evaluation of novel fluoroquinolone-aminoglycoside hybrid antibiotics Bacterial resistance to antibiotics plays a major role in today's medical world. A series of new hybrid antibiotics containing fluoroquinolone and aminoglycoside antibiotics were designed, synthesized and their antibacterial activities were determined. This combination yielded a new superior antibiotic: very potent on the one hand and resistant to bacterial resistance enzymes on the other. Read more...
MED-0949: Detection and diagnosis of chronic renal failure and kidney related diseases by electronic nose End-Stage renal disease (ESRD) is a debilitating medical condition of chronic kidney failure, which requires intensive and costly treatment through dialysis or transplantation. Early screening and intervention may reduce neuropathy progression and may bring to remission increasing. Our suggested technology may be able to differentiate between "healthy" and "renal failure" breath, which may contribute to the early detection of the disease. Read more...
DIA-1061: Detection of ABCG2 activity using OH-bearing Imidazoacridinones Multidrug resistance efflux pumps are a major obstacle to cancer patients' recovery using chemotherapy. Despite the major advance in chemotherapy protocols and the novel potent anti-cancer drugs, chemotherapy of many cancer patients remains statistical and the patient is treated solely based on the pathological diagnosis of his cancer. Application of anticancer drug that is extruded by the MDR pump does not improve the patient's status, exposes him to the harsh chemotherapy side-effects and leads to a tumor which is highly refractory to chemotherapy. In this invention Technion leading researchers have developed a method for identification and quantification of MDR pumps within cancer cells within one hour. Read more...
MED-1299: Differential, calibration-free and reference-electrode-free CMOS ISFET for ions and pH measurements The present invention relates to a novel device for acidity (pH) or ion concentration measurements. The proposed device is differential, calibration-free and reference-electrode free CMOS ISFET with remote sensing antennas. It eliminates the need for costly calibration, provides better stability over time and can be used where minuscule sensors are required, as in in-vivo medical and biomedical applications. Read more...
STM-0613: Differentiated human embryoid cells and a method for producing them The present invention is a process for obtaining human derived embryoid bodies (hEB). It is based on the finding that human embryoid bodies may be obtained in vitro from human embryonic stem cells suspended in a liquid medium. These hEBs contain mesoderm, ectoderm and endoderm cell lineages and may be used as a source of cells of the different lineages. The hEBs can then be used as a source of cells for use in transplantation or inoculation into a human recipient, in order to treat various diseases or disorders, to assist in tissue repair, and to substitute for degenerated tissue. Read more...
STM-0800: Differentiation of human embryonic stem cell into osteoblasts, chondrocytes and tendocytes The present invention describes a method for the efficient derivation of connective tissue progenitors (CTPs) from hES cells. These cells have multi-lineage developmental potential, yet are committed to connective tissue derivatives. Moreover, the potential of these cells to generate tendon-like structures is also shown. By applying the long-term high-density culture technique to these cells, the researchers successfully assembled cylinder-shaped constructs that contained typical ultrastructure characteristics and biomechanical properties of early tendons. Read more...
DIA-1359: Early diagnostic test for parkinson's disease detection Parkinson’s disease (PD) is a common, progressive disorder of the central nervous system. The current method of diagnosing is inefficient and unsatisfactory.
Our innovative solution diagnoses PD, by analyzing particular molecular risk markers in the blood, in the form of the expression levels of multiple, certain genes (a gene panel). This improved method can potentially be distributed as "Kits", increasing their availability, reach and convenience. Read more...
STM-0919: Ectodermal precursor cell line derived from human embryonic stem cells The present invention provides an isolated stable ectodermal IT1 cell line from human ESC, capable of differentiating into epidermal and corneal cells that could reconstitute in vitro pluristratified epidermis and cornea. Applications of this invention include use for pre-clinical trials concerning skin and cornea pathologies, production of transplantable epidermis, repair of wounded corneas and design of cellular models for cosmeto-toxicology. Read more...
RES-0870: Electrical control over antibody-antigen binding Technion inventors have discovered a method to electrically control the binding of an antibody to its antigen. The formation of such bond is highly influenced by surrounding voltage, because the electrical charges of the amino acid's residues in the antibody protein are affected by it. The method facilitates exquisite control over one of the main interactions responsible for biomolecular recognition, which is a prominent function of the immune system. Read more...
MED-0706: Electronic receptor and its application to controlling biological processes The present invention aims at gaining electrical control over biological processes, namely, triggering or suppressing a selected biological pathway by an electronic signal presented to the system. The strategy relies on the selection of antibodies that recognize and bind a specific set of nano-scale electrodes biased to a certain voltage configuration. The implications of such an interface are far reaching. One may envision sensors that probe several biological parameters, converting them into electronic signals. Read more...
STM-0956: Embryonic and adult stem cells encapsulation for cell based therapy and cancer Stem cells are potentially the ultimate source of transplantable cells for many different tissues. A major obstacle in the clinical use of stem cells is their possible immunogenicity. Our technology's innovative approach is to entrap the cells in capsules made of biocompatible polymers. This approach was specifically designed to take advantage of the immortality of these cells, while avoiding any possible immune response or the formation of teratomas. These capsules protect the cells from the immune system and act as a mini bioreactor, allowing them to secrete the engineered factor or natural therapeutic near sites of interest. Read more...
STM-0629: Endothelial cells derived from human embryonic stem cells This innovative technology enables the production of a population of embryonic endothelial cells in vitro from human embryonic stem (ES) cells. The process mimics the differentiation steps of human ES cells into endothelial cells, forming vascular-like structures. Human embryonic-derived endothelial cell behavior was characterized in vitro and in vivo. In vivo, when transplanted into SCID mice, the cells appear to form microvessels containing mouse blood cells. These cells could be beneficial for applications such as engineering new blood vessels, endothelial cell transplantation into the heart for myocardial regeneration, and induction of angiogenesis for treatment of regional ischemia. Read more...
STM-0695: Engineering three-dimensional tissue structures using differentiating embryonic stem cells Human embryonic stem (hES) cells hold promise as an unlimited source of cells for transplantation therapies. The present invention is a method for the control of hES cell proliferation and differentiation into complex, viable 3D tissue constructs. The invention describes the use of biodegradable polymer scaffolds for promoting hES cell growth and differentiation, and for the formation of 3D structures. This approach provides a unique culture system for addressing questions in cell and developmental biology, and provides a potential mechanism for creating viable human tissue structures for therapeutic applications. Read more...
MED-0835: Fast retinal imaging by parallel projections The present invention relates to a device and method for fast retinal imaging and extraction of medical parameters from these retinal images. The innovative technology provides an imaging system that takes a single shot of the retina at various depths, obtaining retinal depth information immediately and providing fast information and continuity of data. The expected price of the system should be less than optical coherence tomography systems, and only slightly more than fundus cameras. Read more...
RES-0837: Floating electrode dielectrophoresis (feDEP) The present invention relates to the use of electrically floating electrodes (fe) for the dielectrophoretic (DEP) manipulation of bioparticles. feDEP is an enabling technology that offers a significant leap towards cheap, disposable, and therefore, commercially available DEP devices. The use of floating electrodes will considerably facilitate device fabrication and operation, as well as reduce device dimensions and offer interconnect-free devices. Also, since floating electrodes do not require an external connection, their geometries are much more flexible. This opens a doorway for using feDEP in cellular patterning and tissue engineering. Read more...
STM-0721: Growth and differentiation of human embryonic stem cells within three dimensional scaffolds The present invention relates to methods for generating embryoid bodies (EB) using three-dimensional scaffolds. The invention describes, for the first time, the generation of EBs on porous scaffolds and demonstrates that hEBs can be generated directly from hES suspensions within 3D porous alginate scaffolds. The scaffold-borne EBs were of a high quality, essentially devoid of necrotic centers, and exhibited a high proliferation rate and differentiation to all three germ layers, while displaying minimal agglomeration. These new methods can be used for isolating multipotent lineage-specific cells and for the large-scale production of lineage-specific differentiated cells. Read more...
DIA-1121: Hand-held probe for in-vivo tooth electron spin resonance (ESR) dosimetry Nowadays when the risk of exposure to doses of ionizing radiation arises, there is an ongoing need for a simple, inexpensive and accurate detecting device for radiation exposure dosage. The new technique based on Electron Spin Resonance (ESR ) measures the absorbed radiation in human tooth enamel. It is perhaps the only such method which can differentiate among dosage sufficiently for classifying individuals that has been exposed. Read more...
DRS-0855: Heterocyclic derivatives, pharmaceutical compositions and methods of use thereof In this invention a new compound, a ligand to the peripheral-type benzodiazepine receptor (PBR), is introduced. The PBR-ligand attachment induces anti-apoptotic activity, which is of extreme value in neurodegenerative diseases and traumatic brain damage. Traumatic brain injury is the leading cause of disability in individuals below the age of 40. Read more...
STM-0923: Identification and selection of cardiomyocytes during human embryonic stem cell differentiation Human embryonic stem (hES) cells are pluripotent cell lines that can differentiate in vitro into cell derivatives of all three germ layers, including cardiomyocytes. The present invention is the generation of transgenic hES cell lines and single-cell clones that express a reporter gene (eGFP) under the transcriptional control of a cardiac-specific promoter. The generation of these transgenic hES cell lines may be used to identify and study early-cardiac precursors for developmental studies, to robustly quantify the extent of cardiomyocyte differentiation, to label the cells for in vivo grafting, and to allow for the derivation of purified cell populations of cardiomyocytes for future myocardial cell therapy and tissue engineering strategies. Read more...
MED-0991: In-vivo flow-cytometry In this invention, a method for imaging the cross section of a vessel for detecting the flow of cells using spectrally encoded imaging was developed. This method provides visual information on the scattering particles, including their size, shape, brightness, as well as their location within the vessel. Such information could significantly increase the accuracy of flow cytometry and provide additional capabilities, such as cell sorting and the modification and destruction of specific cells. Potential applications include in vivo and ex vivo flow cytometry for industrial and clinical applications. For in vivo applications, the compact dimensions and simplicity of the probe, which is approximately 20 x 5 x 5 mm in size with no moving parts, could enable endoscopic flow cytometry in various locations in the body. Read more...
MED-0680: Ion concentration sensor Ion concentration measurements, particularly pH measurements, are performed routinely in the chemical, biochemical, biomedical and other fields. Also, much effort has been invested in creating a combined ion and image sensors for advanced biotelemetry systems. Conventional ion concentration sensors require readout circuitry to convert an electrical response to values corresponding to the ion concentration in the solution. This circuitry increases the size and complexity of the sensor and increases its power consumption. Furthermore, it also adds limitation to the bandwidth and reduces the stability of the sensor. This sensor can perform simultaneous ion and image sensing without readout circuitry creating a critical device for advanced biotelemetry systems that are energy-efficient, compact and reliable. Read more...
STM-0777: L6-IL6 receptor chimera supports the feeder layer-free culture of human embryonic stem cells Human embryonic stem cells (hESCs) have contributed significantly to the research on early human development and may have future application in cell-based therapies. These cells have been cultured on mouse embryonic fibroblast (MEF), causing increased risk for exposure to mouse retrovirus. The present invention provides a new feeder layer-free culture system for undifferentiated hESCs for any industrial or clinical uses. Read more...
CTT-1023: Layered hydrospinning for the production of tissue engineering scaffold Scaffolds seeded with cells are needed for tissue engineering. The present invention utilizes electrospinning with a twist. Instead of spinning on a solid electrode, we spin on the surface of a liquid reservoir. The resulting nanofibrous membrane formed on the surface of the liquid is then assembled on a glass slide, and cells are seeded between each layer. Many such assemblies create a layered scaffold. The final scaffold is put in a vacuum environment, where it swells massively in size. This invention provides a novel scaffold with a few cubic centimeters in volume that is filled with cells and is capable of tasks such as filling a critical gap in bone healing. Read more...
MED-1285: Manipulation of cells using combined opto-acoustic excitation The present invention describes targeted and rapid means for reversible mechanical manipulation of individual cells (e.g. activation of excitable cells such as neurons) using the combined, synergistic action of light and ultrasound. This method provides modulation of the individual cell from distance in a selective, reversible, and rapid way and may be used in various applications as neuron stimulation for inner ear prosthesis, retinal prosthesis, implanted pacemaker and more. Read more...
CTT-0739: Medical scaffold, methods of fabrication and uses thereof The present invention is a method for manufacturing medical scaffolds and their uses in bone repair, and in dental and orthopedic surgeries. The scaffolds are composed of electrospun nanofibers that have a continuous or stepwise gradient of porosity, and an average pore size and weight per volume. The electrospun scaffold has a 3D structure of non-woven uniform, randomly oriented nanofibers with a diameter of 300-500 nm. The combination of the culture of osteogenic cells with an electrospun 3D scaffold provides an in vitro system that simulates the natural 3D environment capable of supporting bone repair.
Note: available for commercialization for applications from the neck down. Read more...
CTT-0838: Mesoscale bioactive 3D electrospun scaffold for bone repair The present invention relates to a 3D cubic mesoscale electrospun fibrous scaffold, suitable for implantation in defective bone. The new technology offers nanoscale fibers (PCL) with embedded hydroxyapatite (HA) particles. The combination of electrospun fibers at the nanometric scale and larger mesoscale HA particles imitates the natural structure of bone matrix. This mesoscale scaffold, combined with ceramics and growth factors, constitutes the optimal scaffold to support proliferation and osteogenic differentiation as well as vascularization. It provides a promising surgical tool for bone tissue engineering for many clinical aspects of orthopedic, cranio-maxillofacial and dental applications. Read more...
DIA-0887: Method and kits for diagnosis of schizophrenia Methods and kits for the diagnosis of schizophrenia, employing mitochondrial complex I as a peripheral biological marker, have been developed. Minimizing the impact of the disease depends mainly on early diagnosis and appropriate pharmacological and psycho-social treatment. At the present, diagnosis is based on the self-reported experiences of the patient, in combination with secondary signs observed by a psychiatrist or clinical psychologist; hence misdiagnosis is not a rare event. The identification of this biological marker provides a more precise diagnosis and prognosis. Read more...
MED-1151: Method for dispersion-controlled adjustment of imaging plane in spectrally encoded endoscopy The SEE-Spectrally Encoded Endoscopy is a new method utilizing a single optical fiber and miniature diffractive optics to encode transverse reflection from a sample. The use of this method dictates the geometry of the focal plane which limits in many applications where the object is in a certain position. The new invention proposes the use of chromatic dispersion management to adjust the depth and angle of the image plane of interferometric SEE. Read more...
MED-1327: Method for optical stimulation and monitoring of neurons The present invention outlines a method for creating a novel neural interface based on optically controlling neurons in a cell-containing hydrogel based transparent transplant. The transplantable neural network could be applicable in various fields. One of the fields is CNS tissue engineering, providing a possible treatment for brain injuries, stroke, neurodegenerative diseases and more. Read more...
MED-1278: Method for spectral imaging using spectral encoding Spectrally encoded spectral imaging is potentially useful in many commercial and scientific applications. The improved SNR (signal-to-noise-ratio) and the simplicity of this approach would offer better alternatives to current spectral imaging systems. Our novel invention has simpler optics and hardware compared to the color filter and interferometric approaches, and has improved SNR compared with point and line scanning techniques. Among other exciting applications, spectral imaging through compact endoscopic probes is possible. Read more...
MED-1265: Method for the fabrication of hollow nanostractures The fabrication of high aspect ratio hollow devices at the submicrometer length scale is an unsolved challenge by conventional techniques. The present invention allows the fabrication of hollow structures of high aspect ratio with a very high throughput, as the entire substrate is processed in parallel. It allows defining structures of different shapes and sizes at a defined position, thus enabling to mix different objects on the same substrate in predefined positions. Read more...
STM-0646: Method of dynamically culturing embryonic stem cells The present invention is a method for dynamically generating human embryoid bodies that can be used for generating lineage-specific cells and cell lines. All potential applications depend on the availability of a controlled scaleable bioprocess of the differentiated cells. The present invention describes the formation of human embryoid bodies (hEBs) in dynamic systems, and discloses simple, culture-specific conditions that allow the formation of hEBs. The initial event participants in the developing hEBs did not change when moved from their conventional culture to dynamic systems, indicating the possibility of simple scaleable cell production in a well-defined dynamic environment for clinical and industrial applications. Read more...
DRS-0606: Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer In the field of Oncology, tumor cells have developed sophisticated strategies to escape immune effector mechanisms. One of the well known escape mechanisms is using the downregulation of MHC class I molecules, which are the antigens recognized by the immune system cells. This invention presents a new recombinant molecule that binds to cancer cells, making them detectable by immune system cells. This new discovery may open the way for the development of new immunotherapeutic strategies. Read more...
DRS-0607: Methods for the preparation of selectively-substituted corroles and new substituted corroles Technion researchers have developed a method for synthesizing selectively-substituted corroles and new substituted corroles. The invention demonstrates that highly selective functionalization of beta-pyrrole-unsubstituted corroles can be used for the easy preparation of novel amphiphilic derivatives and of complexes with metal-centered chirality. These novel compounds may be used for tumor detection and treatment, in photovoltaic devices, as catalysts and as intermediates. Read more...
DRS-0764: Methods for treatment of renal failure Rasagiline is an approved anti-Parkinson drug in Europe and Israel. The present invention describes in vivo experiments demonstrating the improvement in function of hypoperfused as well as normal kidneys pretreated with Rasagiline and its derivatives. Rasagiline derivatives produce significant diuretic and natriuretic responses in association with increased GFR in rats with CHF as well as induce diuretic and natriuretic responses accompanied by improved GFR in the ischemic kidney. It is proposed that this derivative can be used for the treatment of acute and chronic kidney failure. Read more...
STM-0611: Methods of generating human cardiac cells and tissues and uses thereof This new technology consists of a method for generating cells having characteristics associated with a cardiac phenotype. The phenotypic properties of cardiomyocytes derived from human ES (embryonic stem) cells are characterized by cardiac-specific antibodies, confirmed by electron microscopy and RT-PCR of several cardiac-specific genes and transcription factors. Positive and negative chronotropic effects were induced by application of isoproterenol and carbamylcholine, respectively. The generated human ES cell-derived cardiomyocytes displayed structural and functional properties of early-stage cardiomyocytes. Establishment of this unique differentiation system may have significant impact on the study of early human cardiac differentiation, functional genomics, pharmacological testing, cell therapy, and tissue engineering. Read more...
DRS-1170: Methods of treating cancer and tobacco associated diseases Tobacco has been linked to a number of health risks, including severe asthma, fertility problems, hypertension, and osteoporosis. Some TSPO receptor ligands have been found to up-regulate trans-locator proteins (18kDa) (TSPO)-associated pro-apoptotic activity, and can therefore repair damages cause by oxidative stress, including tobacco-associated damage. The invention proposes a method of administering an effective amount of such an agent. Read more...
MED-1193: Microdevice for measuring water content in-vivo and in-vitro Water content in tissue, is strongly associated with ageing and degeneration. Early detection of variations in water content in tissue may be of immense diagnostic benefit and is of crucial importance in preventing future pathological processes. Furthermore, knowledge of water content is also important in applications of tissue engineering. Unfortunately, up to date, simple and direct techniques to evaluate water content in tissue are not available yet.
Our technology proposes a solution to the problem. The technology is minimally invasive, provides real time results and reduces extra manufacturing costs. Read more...
CHM-1097: Microstructure control of ceramic matrix nanocomposites A method facilitating a way to obtain ceramic nanocomposites via a safe and very low cost process yielding ceramics with improved strengths and with a significantly improved Weibull modulus. The material also shows remarkable wear properties. Example applications include ceramic cutting tools, ballistic armor, car brake pads, parts for textile fabrication, advanced ceramics for a multitude of applications in the semiconductor manufacturing industry (e.g. capillaries for wire-bonding), and electronic components. Read more...
STM-0789: Multicellular systems of pluripotent human embryonic stem cells and cancer cells and uses thereof The invention is a novel experimental platform for cancer research that uses human stem cell technology. The process grows human tumor cells in a pre-clinical experimental setting in a tissue micro-environment consisting of differentiated human cells. The multicellular composition is placed in an animal model. The model takes advantage of the potential of human stem cells to differentiate in the experimental setting into any and all of the body’s different cell types, and thus mimics a normal human tissue micro-environment. Read more...
MED-1227: Multifocal ultrasound and its effect on biological tissues, in particular via ultrasound effect on biological membranes Ultrasound has been extensively used for imaging for 60 years, and is now being studied towards clinical therapeutic application. Understanding the basic mechanism of its function is critical. Technion Researchers propose a hypothesis whereby ultrasound induces bubble formation in the intra-membrane space in cells, between the two lipid leaflets. Those bubbles accumulate, creating pockets of gas. As the pockets grow, surrounding structures are being pushed.
A possible therapeutic application of this discovery is in the field of neurophysiology, where the use of multifocal ultrasound on neural tissues is likely to become essential to future treatment for people who have a major deficiency in their sensory systems, such as blindness or deafness. Read more...
NUT-1051: Nano-complexes of beta-lactoglobulin and polysaccharides as vehicles for hydrophobic bioactive molecules Although foods and drinks are enriched today on a wide basis, enriching with hydrophobic content remains a problem. When enriching clear drinks the problem farther complicates since except that the method should protect and solubilize the enriching hydrophobic ingredients, the drink must also maintain its quality of transparency. In this invention compositions and methods for the formation of nanoparticles useful for carrying biologically active molecules were developed. Moreover, this invention provides a solution to clear drinks enrichment with hydrophobic biologically active molecules.
DDL-1022: Nanoencapsulation of chemotherapeutic and other drugs in beta-casein micelles Ideally, all drugs could be taken orally at home, optimizing patient response to treatment, treatment costs and patient quality of life. However, the hydrophobic nature of some drugs, especially chemotherapeutic ones, has prevented us from reaching this ideal situation. In this invention beta-casein (and other casein molecules) micelles are used to encapsulate hydrophobic chemotherapeutic drugs, enabling their oral uptake. These preparations may, of course, be further coated with materials that make them gastro-intestinal tract site specific, as in targeted chemotherapy. Read more...
CTT-0744: Natural acellularized cardiac extracellular matrix for tissue engineering This invention is a cleaning procedure that results in a natural heart-derived cardiac ECM (extracellular matrix) scaffold for cardiac tissue engineering. A natural animal acellularized cardiac ECM as described by the invention is the most suitable scaffold for cardiac tissue engineering: due to the acellularization process it does not evoke an immune response, yet it retains its original properties. The produced scaffolds were shown (in vitro) to support cultures of muscles as well as embryonic stem cell-driven cardiac myocytes. This technology may be used for various purposes in the field of cardiac tissue engineering such as cell support, tissue replacement and tissue remodeling. Read more...
MED-0971: Non-contact holographic stimulation technology for next-generation vision restoration devices A unique technology for direct optical stimulation of neurons has been developed in the Technion. This Technology could have diverse applications in the field of advanced neurological devices and particularly the development of next-generation vision restoration devices.
The new, non-contact method is based on rapid holographic stimulation and enables energy- efficient patterned activation of many neurons with high resolution (single cells) and high light efficiency. Read more...
MED-1405: Noninvasive imaging of flowing blood cells This novel method of noninvasive imaging, which allows visualization of the morphology and dynamics of circulating cells, avoids the need to handle specimens and bypasses the need for exogenous labeling of cells, with potentially toxic dyes. Additional advantages include shortened wait-time, portability and the potential to detect early warning signs before severe medical problems develop. Utilized correctly this could shift high-volume routine tests out of the core laboratory and to point-of-care settings. There are many possible applications such as screening and diagnostics as well as new possibilities in clinical research and practice. Read more...
DRS-1256: Novel antibodies which are able to bind soluble T-cell receptor ligands Type 1 diabetes occurs when the autoimmune destruction of pancreatic beta-islet cells prevents production of the hormone insulin. The present invention utilizes TCR-Like antibodies that can bind MHC II/peptide complexes in a peptide-specific HLA-restricted manner. These TCR-like Fabs represent a valuable tool for studying antigen presentation during autoimmune inflammation, and may constitute novel therapeutic agents for treating human diseases involving excessive immune reactivity. Read more...
DRS-0932: Novel antimicrobial agents Over the past decades, advancement in the field of antimicrobial agents had reduced dramatically illness and death due to infectious diseases. However, almost all the prominent infection causing bacterial strains have developed resistance to antibiotics. The present invention relates to novel antimicrobial agents (polymers) designed for exertion of antimicrobial activity while being stable, non-toxic and avoiding development of resistant strains. Read more...
DRS-1192: Novel class of antibiotics based on naturally lethal peptide sequence The increasing appearance of antibiotic resistant bacteria has raised the need for discovery of new antibiotics. We discovered naturally lethal peptide sequence which can cause inhibition of protein synthesis and arrest of the ribosome function, ending with cell death. This sequence can be used as a compound in novel antibiotics highly specific and very efficient. Read more...
DRS-1087: Novel discovery presenting potent protector against the lethal effect of cigarette smoke Cigarette smoke (CS) is the major risk factor for epithelial cancer in the aero-digestive tract and especially for lung and oral cancers. Technion researchers evaluated the protective effect of D-Penicillamine (PenA) against the lethal effect of cigarette smoke (CS) both in the absence of saliva and in its presence (a most pro-oxidative condition).
This novel demonstration is of paramount importance and can be used to attenuate the risks associated with smoking. Read more...
STM-1290: Novel method to derive extracellular matrix from hES cells and human iPS cells for regenerative medicine applications The extracellular matrix (ECM) composition affects the cell attachment, migration, proliferation and 3D arrangement. This new invention uses differentiated human Embryonic Stem cells (hES) or human induced Pluripotent Stem cells (iPS) to generate ECM for surgical applications. This new invention may be used as a biological a-cellular scaffold with the advantages of homogeneity, availability, bioactivity, biocompatibility and safety for surgical application. Read more...
STM-1209: Novel method to generate induced pluripotent stem cells from keratinocytes from human plucked hair follicle Induced Pluripotent Stem (iPS) cells are human somatic cells that have been reprogrammed to a pluripotent state, resembling human embryonic stem cells. The iPS cells are mostly produced from fibroblasts derived from the skin, a painful procedure that may be problematic in certain patients. Technion researchers have discovered a non-painful method for production of iPS cells from the keratinocytes of the outer root of human hair. Read more...
STM-0630: Novel methods for the in-vitro identification, isolation and differentiation of vasculogenic progenitor cells The present invention is of a simplified and inexpensive method for the in vitro identification, isolation and culture of human vasculogenic progenitor cells. The technology allows for the isolation and enrichment of a common precursor for endothelia, smooth muscle and hematopoietic cells derived from human embryonic stem cells. This precursor has been found to express early endothelial and hematopoietic markers and under specific conditions, it persists in endothelial differentiation, forms vessel-like structures with blood cells, and differentiates into smooth muscle cells (SMC). The method and the progenitor cells described may be used for in vitro vascular engineering, among other things. Read more...
DDL-1160: OAK cochleates: Method and composition for a delivery platform Cochleate structures are essential in drug delivery field and may be used as adjuvants. The current invention suggests the formation of Cochleates from oligy acyl-lysine (OAK) compound. The modified OAK may have favorable properties with regard to cost of production, lack of toxicity, stability and size. Read more...
STM-1148: Pancreatic progenitor enrichment of human embryonic cell culture by GLUT2 sorting Type I diabetes mellitus is caused by an autoimmune destruction of the insulin-producing β cells. The major obstacle in using transplantation for curing the disease is the limited source of insulin-producing cells. The earliest human pancreatic progenitors are marked by the transcription factor pancreatic duodenal homeobox (PDX1). In normal β cells, PDX-1 transactivates the insulin gene and other genes involved in glucose sensing and metabolism, such as GLUT2 and glucokinase. Several protocols have been tested, in order to increase the PDX1 expressing population in differentiating human embryonic stem cells (hES) or human inducible pluripotent stem cells (iPS), in an attempt to obtain pancreatic progenitors cells which may further develop into insulin producing cells. Read more...
DDL-1397: Polysaccharide-extracellular-matrix (ECM) encapsulation for cell and drug delivery Microencapsulation of cells for cell and drug delivery allows therapeutic products to be delivered to physiological targets to help restore lost function. Our invention suggests using Hydrogel-based polysaccharide-extracellular-matrix (ECM) cell capsules as a system for drug delivery. The novel system of adding ECM to the encapsulation allows regulation of relevant cell activities and secretion of drugs. Read more...
DRS-0938: Prevention or reduction of biological injury induced by tobacco related materials through the MPTP/TSPO pathway MPTP and/or TSPO have been previously correlated with various pathologies. However, they have never been correlated with the biological injury induced by tobacco products such as cigarette smoke (CS), nor has it been suggested that MPTP/TSPO related drugs/ligands be used to avoid such pathologies. Initial results of both in vivo and in vitro experiments showed that CS induced a significant alteration in the specific binding capacity of TSPO, which may be related to the pathogenic pathways leading to various CS induced pathologies such as cancer, aerodigestive and lung diseases such as COPD, cardiovascular diseases, oral periodontitis and many others. Read more...
DRS-0933: Prevention or reduction of injury induced by tobacco related materials with the copper chelator D-penicillamine Oral and oropharyngeal cancer, which is usually squamous cell carcinoma (OSCC), is the sixth most common cancer worldwide. It is primarily induced by exposure to tobacco. The present invention describes how, when chelating copper prior to exposure of cells to cigarette smoke (CS) in the presence of saliva, we were able to prevent the induced damage. By adding a copper chelator to lung cancer cells (H1299 cell line), which were exposed to CS in the presence of saliva, we prevented the cell death induced by the synergetic effect of CS and saliva. Read more...
DRS-0601: Prevention or reduction of tobacco smoke-associated injury in the aerodigestive tract of a subject The present invention relates to methods for preventing or reducing pathogenesis of oxidant stress-associated diseases of the aerodigestive tract. The invention describes methods for employing hydroxocobalamin (vitamin B12a, OH-CO), deferoxamine (DES) and possibly reduced glutathione (GSH) to reduce or prevent tobacco smoke-induced cellular or macromolecular damage in the aerodigestive tract. The above chemicals may be applied in cigarettes tobacco filters as well as in other forms, such as toothpaste, powder, liquid dentifrice, mouthwash, denture cleanser, chewing gum, lozenge, paste, gel, aerosol spray or candies. Read more...
STM-1283: Production of corneal tissue equivalents from human pluripotent stem cells In severe cases of corneal diseases such as total limbal stem cell deficiency, allo-grafts are obtained from patient’s relatives or from post mortem donors. This approach is commonly used for years. However, shortage of donors and graft rejection are major drawbacks of this approach. Our novel invention is based on the production of corneal cells from human Embryonic Stem cells (hES), allowing the production of unlimited amount of corneal epithelia ready to be transplanted into injured eye of patient. Read more...
DRS-0816: Redesign of aminoglycosides for treatment of human genetic diseases caused by premature stop mutations Cystic fibrosis, Duchenne muscular dystrophy and Hurler syndrome are some of the diseases caused by nonsense mutations: false stop signals in the DNA sequence that bring about the premature termination of the synthesis of specific proteins. Some aminoglycoside antibiotics have been found effective in overcoming this problem, but they cannot be used clinically due to high levels of toxicity. Technion researchers have successfully synthesized minimally toxic aminoglycosides, with an improved functional activity, which can be used for medicinal treatment. Read more...
DRS-1302: Repairing faulty genes by aminoglycosides Many genetic disorders are cause by nonsense mutations, which result in inactive proteins. Such mutations can lead to fatal diseases such as cystic fibrosis, Tay-Sachs, Hurler syndrome, certain types of cancer and more. Certain aminoglycosides cause ribosomes to read through nonsense stop codon mutations, allowing the formation of full-length proteins, making them effective for treating genetic diseases. Unfortunately, most aminoglycosides are highly toxic to mammalian cells, and therefore typically used only as antibiotics for treatment of life-threatening infections. We have invented a new class of pseudo-trisaccharide aminoglycosides, which have high nonsense mutation suppression activity along with only low toxicity levels in mammalian cells and low antimicrobial activity, making them useful for the treatment of genetic diseases. Read more...
WAT-0848: ROAKs for the capture and concentration of bacteria This is a method for the filtration and concentration of bacterial contaminants. Most water, food, and clinical samples usually contain bacteria below detection limits. This innovative technology proposes a system that assembles the bacteria into a larger mass. The system exploits the affinity of microorganisms for peptidomimetic compound oligoacyllysines (OAKs), which were recently developed by the inventors as antimicrobial agents. OAKs are linked to an inert supporting material (resin), resulting in a resin-linked OAK (ROAK) that maintains high binding affinity for microbial cells. Read more...
COM-1373: Second-order optical coherence tomography Optical coherence tomography (OCT) is advantageous over other biomedical imaging modalities, such as ultrasonography and magnetic resonance imaging (MRI), in terms of resolution. However, it has several inherent limitations which prevent it from taking over from traditional imaging techniques. The most notable of these limitations are: Inability to image fast moving objects (like blood flow), limited penetration of up to 1 to 2 millimeters and slow scanning rates. The presented technology is a new OCT technique based on nonlinear optical effects called Second-Order OCT. The technology offers improved resolution, deeper penetration imaging, faster scanning rates and turbulence free imaging. Read more...
STM-0722: Stem cell lines derived from delayed blastocyst culture and their uses The present invention relates to a method for generating stem cell lines from extended blastocyst cultures (embryos beyond the blastocyst stage). The new technology demonstrates for the first time that multipotent or pluripotent cell lines can be derived from embryos at a later stage than the blastocyst stage. The newly developed method is an opportunity to gain insights into the features of the cells in the post-implantation human embryo – between implantation and gastrulation – using in vitro models. Read more...
STM-1132: Suspension culture for undifferentiated human induced pluripotent cells Induced pluripotent cells (iPS) are cells derived from somatic cells that had shown the ability to differentiate into each cell type of the adult body. However, any future use of these cells in clinic or industry requires efficient defined control system. Technion researchers have discovered a unique suspension culture system for iPS cells consisting of serum replacements and growth factors, allowing their continuous growth in the undifferentiated state. Read more...
STM-1234: Suspension culture for undifferentiated human induced pluripotent stem cells Induced pluripotent cells are pluripotent cells derived from somatic cells. Similar to human embryonic stem cells, they differentiate into each cell type of the adult body. This invention presents a new method of culturing induced pluripotent cells, which may be suitable for clinical and industrial needs. The field of induced pluripotent cells has the potential to dramatically change the treatment of human disease, but the traditional method of culturing those cells is not compatible with any practical future use of them. Thanks to this new technology, it has become possible to culture induced pluripotent cells in a 3D structure without waiving any of the typical features of those unique cells. This is a huge step in the passage to mass production of induced pluripotent cells for therapeutic ends. Read more...
MED-1138: System and method for near surface surgery simulation This novel invention describes a system and method for simulation of near surface surgeries, allowing full visual, audio and haptic imaging. This invention uses a unique prism based mass-spring physical simulation to illustrate necessary operations for near surface (skin) surgeries such as real-time incisions and undermining with force feedback. This tool will allow surgeons to practice surgical procedures near surface without using animals or cadavers. Read more...
DRS-1275: T-cell receptor-like (TCRL) antibodies directed to beta-Islets antigens presented by MHC class II Type 1 diabetes (T1D) occurs when the autoimmune reaction against the pancreatic beta-islet cells prevents production of the hormone insulin. Technion researchers have developed specific antibodies that can bind the MHC II-peptide complexes in a peptide-specific HLA-restricted manner. The antibody binding prevents the binding of T-cells and the following autoimmune reaction which may lead to the development of Type 1 diabetes. Read more...
MED-1152: Techniques for spectrally encoded endoscopy We propose a few innovative techniques for spectrally encoded endoscopy. One technique is a method for multiple-channel spectrally encoded endoscopy (MC-SEE), in which the illumination and the collection of optical paths are separated in space. This invention enables a larger depth of field imaging, speckle noise reducing and signals detection of different excitation and emission wavelengths. The other technique, using dispersion, may be effective in optimizing imaging quality and field of view. Read more...
DRS-1453: The use of D-penicillamine and/or desferal for protecting against irradiation damages Total body and field irradiation from nuclear accidents or radiotherapy has severe, damaging, and sometimes fatal effects on the body. It has been shown that damage from limited field irradiation can be partly prevented by administering zinc-desferal and desferal before exposure to radiation. Our novel pharmaceutical compositions comprise of therapeutically effective amounts of Desferoxamine and Penicillamine with acceptable carriers, which help prevent the damages of irradiation as well as some negative side effects. Read more...
CTT-1164: Therapeutic use of modified endothelial and endothelial progenitor Cells (EPCs) This invention suggests transplanting the gene for the proteins nephrin and podocin, which forms a filtering layer called slit diaphragm, to the Endothelial Progenitor Cells (EPCs). We expect the engineered cells to become a part of the kidneys endothelial layer, forming a new barrier and preventing excessive exit of proteins through the urine. In addition, the special feature of the new layer may be used as a microcapsule. Read more...
STM-0988: Tissue engineering of vascularized cardiac muscle from human embryonic stem cells Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physio-chemical factors to improve or replace biological functions. This technology introduces a novel approach for generating vascularized human cardiac tissue in vitro. The engineered human cardiac tissue exhibited typical structural and functional properties of early-cardiac tissue. In addition, this innovative technology may provide unique applications for tissue replacement therapy and stem cell research. Read more...
DRS-0546: Tricyclic compounds and their uses as antiarrhythmic antifibrillatory and defibrillatory agents The invention here centers on the production of novel compounds with antiarrhythmic, anti-fibrillating activity. Ventricular arrhythmia, such as ventricular tachycardia and ventricular fibrillation (VF), plays a major role in sudden cardiac death. The novel compounds under discussion were shown to be effective ventricular defibrillating drug candidates. They exhibit significant in vivo defibrillatory activity. These compounds also exhibit antifibrillatory activity by elevating the fibrillation threshold potential. All of these behaviors suggest that such drugs could be used to treat VF either by themselves or together with electrical defibrillators. Read more...
DDL-1036: Ultrasound-mediated drug delivery Presently, no vector has been approved by the FDA for in vivo gene delivery due to side effects and the death of patients in clinical trials of viral vectors. Technion researchers have developed a method for using non-viral vectors – therapeutic ultrasound waves for the delivery of genes with or without the help of additives. The uses of the invention are gene delivery for laboratory use as well as gene delivery for clinical applications to most tissues and organs. Currently a gene gun is used in some applications but only for superficial skin delivery with very low and transient transfection. The invention describes using therapeutic ultrasound waves, approved for drug delivery to the skin, for the delivery of naked DNA to most tissues and internal organs. Read more...
MED-0867: Vectorial vortex mode transformation for a hollow waveguide using subwavelength structures Hollow waveguides present an alternative to solid core fibers in the IR regime where suitable optical materials are scarce. Due to their air core, they can also be used for broad-spectrum high power transmission due to small insertion losses. This makes them suitable for use in industrial or medical applications or for spectroscopic and radiometric measurements. Conventional hollow waveguides rely on multimode operation; however, this technology allows for the excitation of only a single waveguide mode making it well-suited for certain devices like hollow waveguide lasers. Read more...
