Active particles for targeted local electroporation and lab-on-a-particle applications

Researcher:
Prof. Gilad Yossifon | Mechanical Engineering

Categories:

Medical Devices

The Technology

Self-propelling micromotors are emerging as a promising micro- and nanoscale tool for single-cell analysis.. The new technology successfully demonstrates that the field gradients necessary to manipulate matter via dielectrophoresis can be induced at the surface of a polarizable active (“self-propelling”) metallodielectric Janus particle (JP) under an externally applied electric field, acting essentially as a mobile floating microelectrode. Accordingly, the external electric field can singularly trap and transport e.g. bacteria and can selectively electroporate the trapped bacteria. Selective electroporation, enabled by the local intensification of the electric field induced by the JP, was obtained under both continuous alternating current and pulsed signal conditions. This approach is generic and applicable to bacteria and JP, as well as a wide range of cell types and micromotor designs. Hence, it constitutes an important and novel experimental tool for single-cell analysis and targeted delivery.

Advantage

  • Simpler and more robust than current systems
  • The mobile microelectrodes also locally intensify the electric field itself
  • A unified optical-based propulsion (thermophoresis) and cargo loading (plasmonic optical tweezer) method

 Applications and Opportunities

  • Novel experimental tools for molecular biology enable Diagnosis of human disease
  • Therapeutics and new testing platforms for cell therapies using DNA, RNA, proteins or drugs
arrow Business Development Contacts
Dr. Gal Gur
Director of Business Development, Life Sciences