The resistance of pathogenic bacteria to antibiotics is a public-health concern in the last decades. Antimicrobial peptides (AMPs) are promising candidates for the development of new drugs as they are active against resistant bacteria and are less prone to induce bacterial resistant compared to small molecules. However, their low bioavailability presents a major drawback to drug development. The technology enables the formation of supramolecular ordered structures of AMPs, in which self-assembly is important for activity.
- Induces less bacterial resistance
- Provide improved bioavailability, stability against heat, shear force, and chemical and proteolytic degradation
- Facilitate adhesion of AMP’s to various surfaces (unable their usage as antibacterial coating materials)
Applications and Opportunities
- Antibacterial drugs
- Coating of implants and indwelling medical devices, catheters, pipes, etc
- A scaffold for functional and durable biomaterials for a wide range of medical and technological applications