Corroles for creating nano-bracelets with selectivity for cancer cells in solid tumors

Researcher:
Prof. Zeev Gross | Chemistry

Categories:

Chemistry and Materials

The Technology

Corroles are tetrapyrrole macrocycles that are closely related to porphyrins, that serve as promising therapeutic agents for a wide range of applications, namely as promising drug candidates for prevention and treatment of diverse diseases, as antibacterial agents as well as bio-imaging agents. Corrole chemistry can be uniquely used in designing corrole-based anti-cancer agents. Corroles function as both therapeutic and imaging agents, with exceptional stability and more readily tunable photophysical properties than porphyrins. Many corroles have been shown to have promising cytotoxic and cytostatic activity. They form covalent conjugates with nanoparticles and noncovalent conjugates with proteins such for targeted corrole delivery, thus can serve as selective therapy for cancer cells in solid tumors.

Advantages

  • Corroles show promising cytotoxic and cytostatic activity
  • Corroles form covalent conjugates with nanoparticles and noncovalent conjugates with proteins such for targeted corrole delivery

Applications and Opportunities

  • Corroles serve as selective therapy for cancer cells in solid tumors
  • Additional applications include treatment for various other diseases, cancer imaging, photodynamic therapy and catalysis
arrow Business Development Contacts
Dr. Gal Gur
Director of Business Development, Life Sciences