Encapsulated mesenchymal stem cells

Prof. Marcelle Machluf | Biotechnology and Food Engineering


Medical Devices | Pharmaceuticals and Biotechnology

The Technology

Stem cells are potentially the ultimate source of transplantable cells for many different tissues. These cells seem to have an unlimited capacity to propagate in culture conditions, while remaining undifferentiated. Furthermore, upon differentiation these cells can transform into many cell types. Stem cells have also been tested successfully for genetic manipulation and gene targeting and cell-based therapy. However, a major obstacle for the clinical use of stem cells is their possible immunogenicity. To date, there is insufficient information regarding the relationship between stem cells and the immune system. The technology focuses on engineering stem cells to produce therapeutics, particularly cancer inhibitors. The innovative approach includes entrapping the cells in capsules made of biocompatible polymers. This approach was specifically designed to take advantage of the immortality of these cells, while avoiding any possible immune response or the formation of teratomas. These capsules protect the cells from the immune system and act as a minibioreactor, which will allow them to secrete the engineered factor or natural therapeutic near sites of interest.


  • Low immunogenicity
  • Possibly autologous
  • Self-renewal, cells Maintained in an undifferentiated state
  • May be transfected with exogenous genes
  • Prevent embryonic stem cells that become teratomas to filtrate to their surroundings

Applications and Opportunities

  • Therapeutics production
  • Transplantable cells
arrow Business Development Contacts
Dr. Gal Gur
Director of Business Development, Life Sciences