The Technology
Neuronal injuries, including traumatic nerve damage and spinal cord injuries, severely impair sensory and motor functions, necessitating precise neuronal regeneration and axonal growth for effective recovery. Current treatments using electrical stimulation with invasive electrodes are limited by their lack of precision, potential for tissue damage, and risk of infection. To overcome these challenges, this innovative technology employs biocompatible silver sulfide (Ag₂S) quantum dots (QDs) designed for electro-optic neuronal stimulation via near-infrared (NIR) light. These specialized QDs possess optimized photocatalytic properties, achieved through precise control of size, doping, and ligand characteristics, enabling safe and effective non-invasive stimulation. In vitro studies demonstrated substantial neuronal proliferation, axonal growth, and network formation upon NIR illumination, indicating significant therapeutic potential.
Advantages
- Non-invasive neuronal stimulation, eliminating risks associated with traditional electrode implantation.
- Demonstrated biocompatibility and no toxicity in vitro.
- Precisely controlled neuronal regeneration and axonal growth.
- NIR activation enables deep tissue penetration and precise spatial-temporal control.
- Minimally invasive and potentially more cost-effective compared to existing therapies.
Applications and Opportunities
- Treatment and rehabilitation for traumatic nerve and spinal cord injuries.
- Applications in neurodegenerative diseases requiring enhanced neuronal regeneration.
- Integration into advanced therapeutic devices for precise neuronal stimulation.
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