The Technology
Tissue bioadhesives are widely used in dermatology, surgery rooms, and in the field. Despite their advantages over sutures and staples, currently available tissue glues are limited by their mechanical properties and toxicity. Here, a new approach is described for wound closure that is based on a biocompatible, low melting point, branched polymer comprising a plurality of biodegradable arms. The branched polymer is inserted into a hot melt glue gun, melts upon minimal pressure, and is extruded directly onto the wound, where it solidifies, bonding strongly with both edges of the wound. Changes in molecular weight allow control of adhesive strength, melting point, and elasticity properties. In vitro and in vivo evaluations confirm the biocompatibility of this system. The straightforward synthetic scheme and the simple delivery method, combined with the desirable mechanical properties, tunability, and tissue compatibility, are desirable traits in wound management.
Advantages
- A new concept for tissue adhesion, based on material solidification rather than on chemical reaction.
- Simple delivery method, combined with the desirable mechanical properties, tunability, and tissue compatibility.
Applications and Opportunities
- Tissue adhesives in dermatology, surgery rooms, etc.
- Formulation can be administrated as is (alone) or with the addition of relevant drugs, such as antibiotics, pain killers, etc.
Business Development Contacts