DNA, due to its remarkable data density and long-term stability, is an appealing potential candidate component of next generation data storage systems, most notably for long term archiving applications. Large scale, high throughput, DNA synthesis technology is needed. However, current DNA synthesis technology offers only limited support for synthetic composite DNA and therefore the potential of the technology remains untapped in both academia and industry. The main limitation of composite DNA synthesis is the scale of the synthesis process.
The inventions enable:
Triplex-based storage-writing/reading/erasing technology
Large scale, high throughput synthesis of composite DNA sequences
Method to encoded information into DNA molecules by combining synthesis of trinucleotides (or other k-mer reagents, k typically being a small number, say between 3 and 10) and a combinatorial sub-set based coding scheme
- Low-energy footprint in long term storage of information
- Compactness of DNA
- Speed of information retrieval. Given DNA’s known read/write limitation
- Accurate decoding , errors and cost reduction
- Complex encoding and higher logical density
- Interaction and nanopore readout allows us to over-come that and access speeds that are hallmarks of current state-of-the-art storage devices.
Applications and Opportunities
- High density and cost effective storage of digital data using DNA molecules (mainly long term archival purposes)
- Low energy and compact data storage device for very large data sets which will target data centers rather than home use New class of local treatment
- Composite of DNA synthesis, DNA based data storage and sequences