The Technology
Cancer immunotherapy shows poor clinical results in many cancer types. A potent suppressor mechanism is the deprivation of required metabolic nutrients from T cells. Tumors compete with T cells for the same essential nutrients including glucose and amino acids, and T cells arriving to the tumor site become exposed to starvation conditions under which they need to undergo activation, leading to hampered T cell activation, differentiation and killing abilities. Currently there is no known proposed solution to overcome metabolic suppression of T cells. The developed technology is an innovative nanotechnology-based approach to overcome metabolic T cell suppression in cancer immunotherapy by delivering essential metabolic nutrients to T cells via nanoparticle encapsulation. The nanoparticles are specifically fed to T cells thus ensuring specific delivery of essential metabolites to T cells and not tumor cells. The metabolites gradually release from the nanoparticles in a controlled release fashion, ensuring essential nutrient supply when the T cells enter the starvation conditions present at the tumor microenvironment.
Advantages
- Novel nanotechnology-based approach for the supply T cells ex vivo with any single metabolite or metabolote combinations
Applications
- Cancer therapy as a standalone adoptive cell transfer monotherpay monotherapy drug or as a new immunotherapy strategy or be combined with existing immunotherapies
Business Development Contacts