Identifying chirality of molecules especially with multiple chiral centers is crucial to the pharmaceutical industry as chirality affect activity, efficacy and even pose safety issues. Currently the molecules chirality identification methods rely on weak signals and requires expensive equipment. Multiple chiral centers can be identified only up to 2 chiral centers and requires complex, time consuming and expensive techniques such as liquid chromatography, gas chromatography, capillary electrophoresis, and nuclear magnetic resonance spectroscopy.
Using ultra-short laser pulses identification and characterization of chirality and enantiomeric excess in a very precise way, with an essentially background free signal, can be done. The general approach applies to any phase of matter (liquid, gas, solid).
- Detection of more than 2 chiral centers
Applications and Opportunities
- Detecting multi-center chiral molecules in the pharmaceutical industry