Early detection of myocardial injury

Researcher:
Prof. Amir Landesberg | Biomedical Engineering

Categories:

Medical Devices

The Technology

Organ failure due to cardiovascular collapse is a leading cause of mortality in all the intensive cardiac units (ICUs). Myocardial injury is the most cardinal problem in this setting, and proper management of myocardial injury requires early detection. Missing the development of myocardial injury may lead to maltreatment, e.g. with fluid overload, that may lead to heart failure and death. The earlier signs of myocardial injury appear in myocardial wall dynamics, especially in the left-ventricle diastolic function1, but there is no continuous monitoring of these changes. Therefore, there is a crucial need to detect the earlier signs of myocardial injury and to provide the needed appropriate treatment. In addition, a simple screening for diastolic dysfunction in the population at risk is an unmet need. Diastolic heart failure is currently the leading cause (>50%) of heart failure and its prevalence is steadily growing. During systole, part of the energy generated by the cardiomyocytes is used to generate the external work (EW) and part is stored within the myocardial wall and is used for at least three additional main goals: (1) Fast myocardial recoil at early diastole, for rapid filling of the heart. (2) facilitation of the coronary blood flow and adjusting the coronary blood flow and oxygen supply to generated work and oxygen consumption, and (3) squeezing out the lymphatic fluids out of the myocardium. Therefore, we have shifted the focus from the cavity volume to geometrical changes in the myocardial wall, which was never described or measured before.

Advantages

  • Move from the Echocardiography room to the Point of care diagnostic.
  • Simple to use- requires simple acquisition of the ventricle short axis.
  • More precise diagnostic and quantification.

Applications and Opportunities

  • Echocardiographic Of Cardiovascular Deterioration.
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Motti Koren
Director of Business Development, Life Sciences