The Technology
Cardiovascular diseases and myocardial infarction (MI) in particular are the leading cause of death in the developed world. The only therapeutic options currently available for end-stage heart failure are mechanical ventricular assist devices or heart transplantation. However, these options have significant cost and availability limitations. Biomimetic scaffolds generally aim at structurally and compositionally imitating native tissue, thus providing a supportive microenvironment to the transplanted or recruited cells in the tissue. Native decellularized porcine extracellular matrix (ECM) is becoming the ultimate bioactive material for the regeneration of different organs. The technology encompasess a matrix that is produced from whole decellularized porcine cardiac ECM using electrospinning technology, has been developed. This unique electrospun cardiac ECM mat preserves the composition of ECM, self-assembles into the same microstructure of cardiac ECM ,and preserves key cardiac mechanical properties. It supports cell growth and function, and demonstrates biocompatibility in vitro and in vivo.
Advantages
- Bioactive
- Biocompatible
- Tissue-specific
- Accurate mixture of active molecules which comprise the natural microenvironment of the cells
Applications and Opportunities
- Cardiac tissue regeneration
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