Gads as an attractive drug target

Researcher:

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Pharmaceuticals and Biotechnology

The Technology

Type I hypersensitivity is a common form of allergy, affecting hundreds of millions of patients around the world, caused by allergen sensitization of immune mast cells. The most commonly-used allergy drugs, anti-histamines, target the symptoms of allergy, but cannot be used to treat long-term consequences of allergy, such as asthma. An alternative approach, immunotherapy, targets the underlying allergic mechanism, however, this approach is allergen-specific, time consuming and expensive. Gads is an adapter protein plays an important regulatory role in allergy, mediated by Gads dimerization and its interaction of the LAT-nucleated signalosome in mast cells. The developed technology offers a novel strategy for treating allergy by directly inhibiting the interaction of Gads with LAT-nucleated signalosome, creating targeted inhibition of mast cell activation.

Advantages

  • Targeting both the sensitization and activation phases of the allergic response
  • Non-dependent on identifying the particular allergens to which the patient is sensitive

Applications and Opportunities

  • Prophylactic treatment during the allergy season, by administering a pharmacologic inhibitor of Gads dimerization
  • Gads dimerization screening platform for drug development
arrow Business Development Contacts
Dr. Gal Gur
Director of Business Development, Life Sciences