Over the past decade it has become apparent that the aging immune system has a fundamental role in a variety of chronic illness, including cardiovascular disease, cancer, neurodegeneration, musculoskeletal conditions and others. This places the immune system as an “aging rheostat” from which we can learn mechanisms of disease, and against which we can intervene.
A metric was developed to reflect the relative location of individuals along the immune-age axis and reflects the biological age of the immune system. This novel metric is associated with cardiovascular malfunctioning and predicts mortality risk beyond well-established risk factors such as age, gender, cardiovascular disease or others. The method can be used, among others, to assess the therapeutic efficacy of agents used to treat immune-related disorders.
- Broad relevance to a variety of chronic illnesses
- High resolution: continuous monitoring of immune state
- High sensitivity: multi-dimensional biomarker
- Early detection
Applications and Opportunities
- Biomarker for the therapeutic efficacy of agents aiming to treat immune-related disorders
- Prevention, monitoring and treatment selection for age-related chronic disease
- Screening for underlying chronic conditions, such as cardiovascular events
- In-Vitro Diagnostics (IVD)