The Technology
BiomarkerFlow is a diagnostic platform that enables rapid, multiplexed detection of biomarkers through advanced computational microscopy and microfluidics. It provides a breakthrough alternative to conventional immunoassays, such as ELISA and ECLIA, by offering faster, more scalable, and cost-effective analysis with minimal sample preparation requirements. The technology is designed to operate at clinically relevant sensitivity – achieving a detection limit of 70 pg/mL using less than 50 μL of sample – and delivers results in under an hour, making it suitable for clinical applications that could benefit from continuous, real-time monitoring of protein-based biomarkers.
Advantages
- Rapid and simple sample processing for time-sensitive clinical workflows.
- Multiplexing capability for simultaneous detection of multiple biomarkers.
- Cost-effective and scalable for both centralized labs and bedside testing.
- Applicable to diverse clinical and research needs.
Applications and opportunities
- Transplantation and Cell Therapy Monitoring – for early detection of cytokine dynamics and immune dysregulation during and after treatment, supporting predictive interventions. Examples include early detection of CAR-T-associated toxicities and Graft-versus-Host Disease (GVHD).
- Allergy Monitoring and Management – Detecting and tracking IgE and inflammatory markers to monitor allergy status, prevent severe reactions, and personalize desensitization protocols.
• Hormone Replacement Therapy (HRT) – Monitoring of hormonal biomarkers (e.g., estrogen, testosterone) to tailor and adjust HRT regimens for optimal therapeutic benefit. - Companion diagnostic – enabling real-time monitoring of disease-specific biomarkers to guide personalized treatment decisions. Its integration into clinical workflows will support early detection, therapy selection, and response monitoring, enhancing treatment precision and outcomes.
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