The Technology
This innovative gene expression system introduces a universal method to enhance protein production in eukaryotic cells, including mammalian and yeast systems. The technology employs synthetic upstream regulatory sequences (sURS) designed with characterized motifs to significantly boost gene expression levels by 300% to 1200%, depending on the promoter and motif configuration. These sequences are embedded within a computed non-binding “dessert” sequence, ensuring compatibility and universality across diverse promoters and cell types.
The system’s modular design allows for controlled expression amplification tailored to the desired application, from biologics production , rare earth elements (REE) extraction, to alternative protein manufacturing. It addresses key limitations of current systems, such as low expression titers and a lack of flexibility, making it ideal for clean-tech, food-tech, pharmaceutical, and synthetic biology applications.
Advantages
- High Efficiency: Increases protein expression by 300%-1200%.
- Universality: Applicable to mammalian, yeast, and fungi cells for diverse gene expression needs, especially for protein secretion application (e.g. REE extraction).
- Customizable: Controlled expression levels through adjustable motif configurations.
- Cost-Effective: Reduces production costs by improving yields in scalable systems.
- Versatile: Supports a wide range of applications, from therapeutics, clean-tech, to food industry innovations.
Applications
- Pharmaceuticals: Over-expression of biologics in mammalian cells for therapeutic application.
- Food-Tech: Production of alternative proteins in yeast cells for sustainable food solutions.
- Synthetic Biology: Creation of gene circuits and advanced cellular programming.
- Clean-tech: Utilization in multiple waste streams to extract valuable commodities in a clean and cost-effective fashion.
This universal over-expression system provides a robust and adaptable solution for overcoming existing challenges in protein production, fostering innovation in key industrial sectors.
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