Scaffolds from electrospun decellularized extracellular matrix

Prof. Marcelle Machluf | Biotechnology and Food Engineering


Pharmaceuticals and Biotechnology

The Technology

Tissue engineering has emerged as a promising approach to improve or restore the function or shape of a damaged tissue or organ by implantation of polymeric scaffolds, functional cells, or their combination in cell seeded scaffolds. Most of the currently available techniques drawbacks, however, are limited biocompatibility and the absence of any biological activity. In view of these drawbacks, newly developed technologies were employed to produce scaffolds of better controlled properties. One such technology is electrospinning, which provide a bottom-up approach where the fibers are spun into a matte in an organized, homogeneous manner.


  • Provide more cytocompatible environment for the cells than synthetic scaffolds
  • Preserving the original ECM composition of a specific organ
  • Provides the cells with an organ-specific environment promoting cellular viability
  • Provides specific ligands for cell adhesion and migration, thus regulates cell proliferation
  • Eliminates adverse immune responses
  • Provides controllable homogeneous-sized fibers, distribution, and dispersion within the mesh of the scaffold material
  • Provides a uniform thickness of the scaffold that can be controlled as desired
  • Provides a mesh capable for entrapping cells, therapeutics or nano and micro delivery systems

Applications and Opportunities

  • ECM fibers. Production
  • Regenerative medicine: Delivery; Research methods and models
arrow Business Development Contacts
Motti Koren
Director of Business Development, Life Sciences