Flow cytometry is a high-throughput system enabling the rapid characterization of cellular populations. Compared to traditional imaging methods, this accelerated process makes it possible to collect a sufficient quantity of data needed to analyze even small subpopulation with statistical significance. Yet, flow cytometry generally provides limited information particularly lacking detailed spatial information, e.g., depth information and three-dimensional imaging. There is no existing method for high-throughput three-dimensional microscopy.
The patented technology consists of an apparatus, systems, and methods for facilitating three-dimensional imaging of an object, e.g., a fluorescent particle such as a fluorescently labeled cell, in high-throughput systems, such as Imaging flow Cytometry.
- Combines ultra-high throughput and measurement of 3D structures (i.e. quantity & quality)
- May be integrated into an existing imaging flow-cytometer
Applications and Opportunities
- Imaging of microscopic biological specimen
- Drug discovery