The Technology
Solid tumors treatment is a significant challenge. Solid tumors present a complex microenvironment that severely restricts the penetration of therapeutic agents, leading to suboptimal therapeutic efficacy due to
a. Dense Extracellular Matrix which creates a physical barrier
b. High Interstitial Fluid Pressure further limits the movement of drugs within the tumor
c. Aberrant Vasculature leading to inefficient drug delivery and distribution
d. Heterogeneous Cellular Environment causes complex drug penetration
Current solutions are not effective and poses toxicity issues. Others are simply expensive.
Using a novel high throughput assay based on 3D tumor spheroids and AI, a novel compound was developed to improve the penetration of therapeutic agents into solid tumors and to stabilize nanoparticles for drug encapsulation. It was shown to be safe and effective in several challenging pre-clinical mice models of squamous cell carcinoma of the head and neck.
Advantages
- Enhanced Drug Penetration into Solid Tumors
- Nanoparticle Stabilization
- Improved Oral Bioavailability of Drugs with Low Absorption
Applications and Opportunities
- Enhanced Drug Delivery in Oncology
- Nanoparticle Stabilization
- Improving Bioavailability
Business Development Contacts