The Technology
This waveguide-enhanced nanopore system enables solid-state, single-molecule detection with high sensitivity and optical precision. It integrates a metallic nanowell structure with a nanopore drilled into a silicon nitride membrane, combining optical waveguiding with ionic current sensing to achieve dual-mode detection. The waveguide illumination permits highly multiplexed imaging of nanopore arrays, hence addressing the need for high-throughput sensing application in emerging protemics, genomics or metanolomic fields.
The system is designed to detect and analyze individual biomolecules—such as DNA, RNA, and proteins—by monitoring their translocation through the nanopore. This approach allows for the detection of genetic mutations, epigenetic markers, and nucleic acid modifications, even at extremely low concentrations. It addresses a critical need for highly sensitive and accurate biomolecular analysis in fields such as early disease diagnostics, precision medicine, and pharmacogenomics.
By concentrating the electromagnetic field and suppressing background fluorescence, the system achieves a high signal-to-noise ratio, enabling real-time monitoring of molecular events, and at the same lend itself for massive parallelism for the iulumination of thousands of nanopores simulatneously. The electrical signal provides timing and gating, while the optical signal delivers high-resolution fluorescence data. The platform is compatible with scalable, wafer-level fabrication, making it suitable for integration into high-throughput biosensing workflows.
Advantages
- Enhanced signal-to-noise ratio
- Real-time, synchronized dual-mode detection
- Massive paralleilsm for high density nanopore arrays
- Compatible with wafer-scale fabrication
Applications and Opportunities
- Single-molecule DNA and RNA and epigentic modification analyses
- Single molecule protemics
- Ultra-sensitive diagnostics and sequencing
- Precision pharmacogenomics
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