A novel cancer immunotherapy approach
Cancer immunotherapy shows poor clinical results in many cancer types, due to deprivation of required metabolic nutrients from T cells - tumors compete with T cells for the same essential nutrients including glucose and amino acids. Once T cells arrive...
Categories:
Therapeutics & Diagnostics
Advanced, long term disinfectant polymers
Surfaces contaminated with viruses such as the Coronavirus may infect people touching them or facilitate their spreadability. On non-porous surfaces, the viable virus can be detected for days to weeks. Current small molecules-based disinfectants are effective in cleaning surfaces, but...
Categories:
Chemistry & Materials|Therapeutics & Diagnostics
AI-powered omics prediction from histology for enhanced diagnostics, response prediction and explainability
Technology This AI-driven technology predicts omics signatures directly from histological biopsy images, transforming standard pathology into a multi-omics-powered diagnostic tool. The method integrates machine learning to map molecular data onto histology, enabling precise prognosis and personalized treatment decisions. Tested on...
Categories:
AI & Data Science|Medical Devices & Digital Health|Therapeutics & Diagnostics
An ultra-sensitive nanopore biosensors for detection of KRAS mutations in colorectal cancer
One of the main challenges impeding genomic-based disease identification and characterization stems from the fact that related analytes, such as pathogens genes and cancer biomarkers, are present in extremely low concentrations in biomedical samples. Thus, currently, most clinical genomic identification approaches...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
New antibiotics are a necessity in today’s modern medicine due to the increasing prevalence of antibiotic resistant strains of pathogenic bacteria. There are many attempts at providing new antibiotic drugs by either modification of existing drugs or by finding new...
Categories:
Chemistry & Materials|FoodTech & Biotechnology|Therapeutics & Diagnostics
Antibacterial treatment using aminoglycosides as catalytically disable bacterial ribosome
The emergence of multidrug-resistant pathogens that are resistant to most currently available antibiotics is a significant clinical problem. The development of new antibacterial agents and novel approaches is therefore extremely important. One innovative approach is the development of catalytic antibiotics:...
Categories:
Therapeutics & Diagnostics
Approach for targeted eradication of multidrug-resistant cancer
The frequent emergence of anticancer drug resistance continues to be a major impediment towards curative chemotherapy of various human cancers. Multidrug resistance (MDR) to multiple anticancer drugs is perhaps the most extensively studied major mechanism of anticancer drug resistance. MDR...
Categories:
Therapeutics & Diagnostics
Bio-convergent approach for predicting clozapine response in schizophrenia
Schizophrenia (SZ) is a severe, incurable chronic psychiatric disorder with a worldwide prevalence of about 1% and a peak onset in late adolescence or early adulthood. The disorder is characterized by disturbances in the main human capabilities - perception, emotion,...
Categories:
AI & Data Science|Medical Devices & Digital Health|Therapeutics & Diagnostics
Biosurgery based on enzymatic collagenase
Overexpressed extracellular matrix (ECM) in liver fibrosis limits drug penetration into the tumor and is associated with poor prognosis. Collagen, a triple-helix protein, is the main structural component in such diseases. Collagen viscoelastic properties play a major role in constructing...
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Therapeutics & Diagnostics
Bone marrow-targeted nanoparticle therapy
Treatments for bone-related diseases are limited due to significant side effects, lack of effective disease management, drug challenges, bone barrier leading to low drug concentration in bone. Bone marrow-targeted liposomes (BMTL) represent a novel nanomedicine platform designed to enhance the...
Categories:
Therapeutics & Diagnostics
Brain modulation for immune system regulation (specific to the reward system)
We show in mice that through activation or inhibition of the dopaminergic neurons in the Ventral Tegmental Area (VTA) in the brain we can alter the immune response. We can control the activity of distinct immune cell lineages, and in...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Cancer diagnostics of biopsies measured by spectral imaging
Cancer diagnosis from biopsies traditionally relies on manual microscopic examination by pathologists, a method prone to variability and errors due to increasing demand and shortage of trained personnel. This groundbreaking technology employs advanced spectral imaging combined with artificial intelligence (AI)...
Categories:
AI & Data Science|Medical Devices & Digital Health|Therapeutics & Diagnostics
Cancer immunotherapy by nanoparticle-based magnetic support in T cells
Cancer immunotherapy shows poor clinical results in many cancer types. A potent suppressor mechanism is the deprivation of required metabolic nutrients from T cells. Tumors compete with T cells for the same essential nutrients including glucose and amino acids, and...
Categories:
AI & Data Science|Medical Devices & Digital Health|Therapeutics & Diagnostics
Cell invasiveness is a major step in tumor metastasis therefore its evaluation is critical for prognosis of cancer progression and will affect treatment protocols. Currently, metastasis prognosis is based on subjective clinical judgment, patient characteristics, disease statistics, tumor shape/size, lymph-node...
Categories:
FoodTech & Biotechnology|Medical Devices & Digital Health|Therapeutics & Diagnostics
Combination of CBD and CBDV for regulation of CXCR4 expression on immune cells
CXCR4 is a membranal chemokine receptor expressed at different levels by all immune cells, and plays a homeostatic role in homing and retention of immune cells. In addition, this receptor is one of the co-receptors for HIV, is expressed by...
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Therapeutics & Diagnostics
Condensed progesterone hormone microcrystals with controlled polymorphism and elongated release
Progesterone, a critical steroid hormone, regulates numerous reproductive functions and has wide-ranging clinical applications, including hormone replacement therapy, contraception, and pregnancy maintenance. Despite its essential role, progesterone is poorly water-soluble, limiting its effectiveness when administered through conventional routes. To address...
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Therapeutics & Diagnostics
Crystals for compounds entrapment and slow release
Drug delivery with slow release systems main limitation is control over the dissolution rate of the encapsulating material as well as leaching of the active material from the encapsulation. Bio-inspired approach in which drugs are entrapped within a crystalline lattice...
Categories:
Chemistry & Materials|Therapeutics & Diagnostics
Cytokine-mediated immunomodulation for the treatment of heart failure and fibrosis
Heart failure and fibrosis represent significant unmet medical needs, with current treatments often limited in effectiveness and long-term management. This innovative technology leverages cytokine-mediated immunomodulation, using a proprietary combination of cytokines to treat cardiac dysfunction and fibrosis. This therapeutic strategy...
Categories:
Therapeutics & Diagnostics
Determining responders to inflammatory bowel disease treatment
Current treatment of Inflammatory bowel diseases (IBDs) is an empiric process, which involves decisions based on the response to therapies by the average patient, without taking into account the basic differences between patients, their specific immune status at a given...
Categories:
AI & Data Science|Medical Devices & Digital Health|Therapeutics & Diagnostics
Developing a novel powerful treatment for inflammatory diseases
Inflammatory bowel disease (IBD) can be debilitating, causing long-term, impaired gastrointestinal structure and function. Until now, no cure has been found and existing treatments can have strongly detrimental side effects. Iron is an essential nutrient that participates in many central...
Categories:
FoodTech & Biotechnology|Therapeutics & Diagnostics
Development extracellular arteries skeleton with a small diameter vascular tissue engineering
Heart failure is a key factor in morbidity and mortality in the western world. Heart muscle tissue differentiates shortly after birth, with the result that cardiac cells lose their ability to divide. As a result, the heart muscle tissue cannot...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Diagnosis of Transient Neonata Deficiency (TNZD) using maternal breast milk cells
The present technology describes a novel genetic diagnostic method for Transient Neonatal Zinc Deficiency (TNZD) using maternal breast milk cells, for early diagnosis as well as prevention.Zinc deficiency is very common worldwide and although actual prevalence figures are not known,...
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Therapeutics & Diagnostics
While biological systems are inherently fuzzy and contain imprecise parts that collectively interact, synthetic computation in living cells is mostly inspired by precise computer engineering principles. Lab research demonstrated that neuromorphic synthetic genetic circuits can be engineered in living cells,...
Categories:
AI & Data Science|Therapeutics & Diagnostics
Early detection of myocardial injury
Organ failure due to cardiovascular collapse is a leading cause of mortality in all the intensive cardiac units (ICUs). Myocardial injury is the most cardinal problem in this setting, and proper management of myocardial injury requires early detection. Missing the...
Categories:
AI & Data Science|Medical Devices & Digital Health|Therapeutics & Diagnostics
Elimination of IgE antibodies to abolish IgE-mediated allergies
Allergic diseases, driven primarily by immunoglobulin E (IgE) antibodies, pose a growing global health challenge, affecting millions worldwide. Current treatments, including anti-IgE therapies like omalizumab, are limited by adverse reactions, partial effectiveness, and development of resistance. Our innovative technology introduces...
Categories:
Therapeutics & Diagnostics
Engineered bacteriophages for therapeutic applications
This innovative platform leverages engineered bacteriophages to modulate the gut microbiome, targeting both infectious diseases and gut-microbiota-related disorders. These engineered phages offer a precision-targeted approach, interacting with bacterial communities in the gut microbiome to fine-tune microbe-host interactions and improve health...
Categories:
Therapeutics & Diagnostics
Enzyme mediated fibronectin inhibition for treatment of fibrosis
Fibrosis is the abnormal accumulation of fibrous extracellular matrix, causing a group of conditions known as fibrotic diseases, such as cystic fibrosis, systemic sclerosis and scleroderma. Fibrosis can be a primary condition or a secondary response, as well as promote...
Categories:
Therapeutics & Diagnostics
Fibrin matrix for engineering tissue substitutes with internal blood vessel network
Tissue engineering holds enormous potential to replace or restore the function of damaged tissues. However, the most successful applications have been limited to thin avascular tissues such as skin and cartilage in which delivery of nutrients and oxygen relies on...
Categories:
FoodTech & Biotechnology|Medical Devices & Digital Health|Therapeutics & Diagnostics
Glucose and lactate continuous monitoring
A great effort has been made to establish efficient electron transfer between electrodes and enzymes. The protein shell of the enzyme prevents electrical communication with electrodes, therefore, redox mediators are required for activation. present new methodology to establish efficient electron...
Categories:
FoodTech & Biotechnology|Medical Devices & Digital Health|Therapeutics & Diagnostics
Harnessing synthetic optogenetic circuits for cancer therapy
Cancer immunotherapy is associated with on-target, off-tumor cytotoxicity or immune-related adverse events. Thus, light-based techniques, optogenetics, could allow “remote control” of immune responses within the body. Harnessing synthetic biology, optogenetics, the use of light to control the activity of specific...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
High-resolution immune-aging profiling and cardiovascular risk
Over the past decade it has become apparent that the aging immune system has a fundamental role in a variety of chronic illness, including cardiovascular disease, cancer, neurodegeneration, musculoskeletal conditions and others. This places the immune system as an “aging...
Categories:
AI & Data Science|Medical Devices & Digital Health|Therapeutics & Diagnostics
Hybrid polymer/lipid drug delivery system for treating oral cancers
Diseases of the oral cavity, including gum disorders, tooth decay and loss, and oral cancers, affect half of the human population. Specifically, incidences of oral cancers have risen by 35% over the past decade, with limited treatment modalities. Administering anti-cancer agents...
Categories:
Therapeutics & Diagnostics
In vitro model of heart failure with preserved ejection fraction (HFpEF)
Heart failure with preserved ejection fraction (HFpEF) is a non-infectious pandemic affecting more than 1% of the general population and more than 10% of individuals over the age of 65. Currently, there are no effective treatments for HFpEF, mainly due...
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Medical Devices & Digital Health|Therapeutics & Diagnostics
Interspecies intestinal co-culture for simple screening of foods and drugs
To meet a growing world population’s nutritional needs, novel foods and especially protein sources are developed, and need to be tested for their physiologic effects on the gastrointestinal tract. The gastrointestinal tract is a complex tissue that can be analyzed...
Categories:
FoodTech & Biotechnology|Therapeutics & Diagnostics
Metabolic biomarker platform for predicting immunotherapy outcomes
Immunotherapy has revolutionized cancer treatment, but patient response remains unpredictable, with success rates varying significantly across different cancer types. This technology introduces a metabolic biomarker platform derived from single-cell RNA sequencing of tumor-infiltrating immune cells. By analyzing over one million...
Categories:
AI & Data Science|Medical Devices & Digital Health|Therapeutics & Diagnostics
Metabolic interventions to enhance immunity in elderly
With aging, immune function, particularly T cell responses, decline, affecting the efficacy of vaccinations and increasing susceptibility to infections. Recent research has identified that the aging spleen’s microenvironment, rich in toxic heme and iron depositions, contributes significantly to this immune...
Categories:
FoodTech & Biotechnology|Therapeutics & Diagnostics
Methacrylated fibrinogen hydrogel precursors
Technology Hydrogel biomaterials that are biodegradable are often sought in the field of regenerative medicine and 3D bioprinting. Biomedical hydrogels comprised of natural polymers such as chitosan, alginate, gelatin, albumin, fibrin and collagen have gained interest for their inherent biocompatibility...
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FoodTech & Biotechnology|Medical Devices & Digital Health|Therapeutics & Diagnostics
Methods determining predisposition to develop kidney diseases
Chronic Kidney Disease (CKD) is a powerful independent risk factor for cardiovascular disease and death at all stages. Most patients with CKD will succumb to cardiovascular complications rather than reach end-stage kidney disease (ESKD). Recent reports estimate that as many...
Categories:
Therapeutics & Diagnostics
Methods of determining prognosis of sepsis and treating same
Sepsis is a severe life-threatening systemic inflammatory response related to infection that is responsible for more than 750,000 deaths annually in the US. It is a systemic inflammatory response syndrome (SIRS) with proven or probable infection of bacterial, fungal or...
Categories:
Therapeutics & Diagnostics
Microfluidic device that is designed to mimic the geometry of a section of the pulmonary acinus
Assessing deposition levels of air-borne particulate matter in the pulmonary acinus is of utmost importance for the pharmaceutical industry where such knowledge is required for development and quality validation of inhaled aerosolized drugs. In addition, deposition levels of toxic particles...
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Chemistry & Materials|Medical Devices & Digital Health|Therapeutics & Diagnostics
Mitochondria tracking using Myosin 19 peptide
Mitochondria are found in almost all eukaryotic cells and play a role in processes such as ATP production, calcium homeostasis, lipid synthesis and apoptosis signaling. Mitochondria are organized as a network that undergoes constant events of fission and fusion, processes...
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Therapeutics & Diagnostics
Neural inhibition for treating bowel diseases
Researcher:
Prof. Asya Rolls
Inflammatory Bowel Disease (IBD) is a group of complex inflammatory disorders involving the gastrointestinal tract. It is a chronic condition with no medical cure, which commonly requires a lifetime of care. To this day, the mechanism of the disease's pathophysiology is...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Neurofeedback and induction of an immune response
Researcher:
Prof. Asya Rolls
Recently, a causal link between activation of the reward system and an immune function was reported in mice. This discovery holds great potential for improving personal health management, rationalizing the use of reward-related brain activation to enhance immune function. The...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Neuronal modulation to control the immune response
Researcher:
Prof. Asya Rolls
We show in mice that through activation or inhibition of the dopaminergic neurons in the Ventral Tegmental Area (VTA) in the brain we can alter the immune response. We can control the activity of distinct immune cell lineages, and in...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Novel fluoroquinolone-aminoglycoside hybrid antibiotics
The emergence of multidrug-resistant pathogens that are resistant to most currently available antibiotics is a significant clinical problem. The development of new antibacterial agents and novel approaches is therefore extremely important. Due to the emergence of new resistance, a strategy...
Categories:
Therapeutics & Diagnostics
Novel Immunotherapeutic Approach for Potent Tumor Rejection
Adoptive T cell therapy has the potential to enhance antitumor immunity, augment vaccine efficacy, and limit graft-versus-host disease. One strategy is the idea of activating and re-directing endogenous T cells, and one way to do this is to use bispecific...
Categories:
Therapeutics & Diagnostics
Novel LAG-3 antibody for treatment of influenza virus infections and autoimmune diseases
Researcher:
Dr. Yotam Bar-On
Lymphocyte Activation Gene 3 (LAG-3) is an immune checkpoint receptor that plays a critical role in regulating immune responses. While extensively studied in cancer immunotherapy, new research reveals that LAG-3 directly binds to influenza virus hemagglutinin (HA), suppressing antiviral immune...
Categories:
Therapeutics & Diagnostics
Novel mitochondrial target unlocks new paths in schizophrenia
Technology Mitochondrial dysfunction is a key driver of schizophrenia. Our research identifies the pseudogene NDUFV2P1 as a major regulator of the mitochondrial Complex I subunit NDUFV2, directly impacting neuronal energy balance and function. The pseudogene is overexpressed in SZ, suppressing...
Categories:
Therapeutics & Diagnostics
Novel mucoadhesive nanoparticles for Cannabinoids delivery to the eye
Topical, systemic, and/or injected corticosteroids are currently the best and most common options available for the treatment of ocular inflammation (uveitis). However, these treatments often cause mild to severe side effects. Cannabidiol (CBD) and other lipophilic cannabinoid molecules have been...
Categories:
Therapeutics & Diagnostics
Novel peptide as a treatment for Parkinson's disease
Parkinson’s disease is a very common neurodegenerative disease. It affects at least 1% of the population above the age of 65. Although there is palliative treatment for the disease's motor symptoms, there is no treatment to prevent or decrease the...
Categories:
Therapeutics & Diagnostics
Novel treatment for diseases requiring long-term repression of gonadal steroids
There is a need to repress production of steroids by the gonads (testes and ovaries) in various “steroid-dependent” diseases, most notably breast and prostate cancers, and uterine fibroids and endometriosis. Current treatments rely on GnRH agonists which shut-down the reproductive...
Categories:
Therapeutics & Diagnostics
Pancreatic extracellular matrix for diabetes cell-based therapy
Microencapsulation of cells for cell and drug delivery is one of the most important approaches for the continuous delivery of this therapeutics. This powerful technique allows controlled delivery of therapeutic products to specific physiological sites in order to restore lost...
Categories:
FoodTech & Biotechnology|Therapeutics & Diagnostics
Peptides for targeting ubiquitin chains in melanoma
A promising approach in cancer therapy is to find ligands that directly bind ubiquitin (Ub) chains. However, finding molecules capable of tightly and specifically binding Ub chain is challenging given the range of Ub polymer lengths and linkages and their...
Categories:
Chemistry and Materials - OLD|Therapeutics & Diagnostics
Personalized clinical decision support for heart failure patients
Technology Heart failure remains a leading cause of mortality, with 20% of patients dying within one year of diagnosis and 50% within five years. Current treatment approaches are often generalized and fail to account for the complex interplay between heart...
Categories:
AI & Data Science|Medical Devices & Digital Health|Therapeutics & Diagnostics
Phase variation mechanisms in bacteria for therapeutic and diagnostic applications
This innovative platform focuses on phase variations (PV) dictated by a reversible genomic mechanism that bacteria use to adapt to changing environments in order to alter gene expression states. PV directly impacts bacterial surface components, immune evasion, and microbe-host interactions....
Categories:
FoodTech & Biotechnology|Therapeutics & Diagnostics
Polymer-conjugated albumin hydrogels for controlled release of therapeutic agents
One of the known functions of serum albumin is the binding and transport of various molecules in the blood circulation, including fatty acids, bilirubin, hormones, metal ions and other endogenous and exogenous compounds with widely differing properties. Among other substances,...
Categories:
Chemistry & Materials|Therapeutics & Diagnostics
Post-functionalization mechanophores via Click Chemistry
The autonomous detection of mechanical stress in plastics and polymers (both biological/natural and synthetic) traditionally requires the incorporation of mechanophores (force-sensitive molecular probes) during the chemical step - polymerization, and therefore does not allow for incorporation after processing. In addition,...
Categories:
Automotive, Aerospace & Industry 4.0|Chemistry & Materials|Therapeutics & Diagnostics
Precision medicine for autism, intellectual disability, and epilepsy
A rare mutation in the IQSEC2 gene results in a phenotype of severe intellectual disability, autism spectrum disorder, and drug resistant epilepsy. Herewith is a set of technologies and capabilities centered around the goal of finding a therapy to improve the lives...
Categories:
Therapeutics & Diagnostics
Proteomics and genomics applications for electrokinetic focusing of in single-molecule sensor
The present patented technology is in the field of single-molecule detection in cases where the source sample is extremely dilute to the point where measurement is prohibited. Single molecule nanopore biosensors are integrated down-stream of a fluidic device that features...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Proteomics in single-molecule sensor
The present patented technology is in the field of single-molecule detection in cases where the source sample is extremely dilute to the point where measurement is prohibited. Single molecule nanopore biosensors are integrated down-stream of a fluidic device that features...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Radar-based imaging system for non-invasive tracking of gold nanoparticles
This technology introduces a non-invasive deep-tissue imaging system that uses millimeter-wave (mmWave) radar to detect and track gold nanoparticles (GNPs) in biological tissues. The system transmits low-power, non-ionizing radar signals and analyzes their reflections to localize and monitor the spatial...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Rapid clinical antimicrobial susceptibility diagnostic system
Technology By the year 2050, antimicrobial resistance is predicted to cost the world over 100 trillion US$ cumulatively and claim 10 million lives per year. Thus, there is an urgent need to develop diagnostic methods that will help physicians to...
Categories:
FoodTech & Biotechnology|Medical Devices & Digital Health|Therapeutics & Diagnostics
Redesign of fluoroquinolones to catalytically fragment chromosomal DNA
Fluoroquinolones are highly potent, broad spectrum antibiotics that are among the most prescribed antibacterial in the world. They exert a bacteriostatic effect by selectively binding to the bacterial topoisomerase IIA− DNA complex and thereby inhibiting DNA replication. At higher doses...
Categories:
Therapeutics & Diagnostics
Scaffolds from electrospun decellularized extracellular matrix
Tissue engineering has emerged as a promising approach to improve or restore the function or shape of a damaged tissue or organ by implantation of polymeric scaffolds, functional cells, or their combination in cell seeded scaffolds. Most of the currently...
Categories:
FoodTech & Biotechnology|Therapeutics & Diagnostics
Self-activating light-generating proteins for synthetic cells
Optogenetics utilizes light-responsive biological components, mostly proteins, to activate cellular processes in engineered and natural cell systems. To optically control these processes, exposure to a light source is required. Therefore, the use of these proteins for therapeutic applications in vivo...
Categories:
Therapeutics & Diagnostics
Self-healing multifunctional wound dressing
Traditional wound closure methods, including sutures, staples, and medical adhesives, have been widely used in the medical field. However, these methods often lead to complications due to mechanical mismatches with the skin's natural properties. These complications may include infection, damage...
Categories:
Chemistry & Materials|Medical Devices & Digital Health|Therapeutics & Diagnostics
Semaphorin 3A as a diagnostic marker for urothelial cancer
Upper urinary tract carcinoma is a highly challenging disease to diagnose and follow. In contrast to bladder cancer, upper tract tumors are more difficult to diagnose and treat, due to the anatomical considerations and the special medical equipment that is...
Categories:
Therapeutics & Diagnostics
Separation of short nucleic acid molecules and quantification of small RNA
Small RNAs are a 20-30b long RNA molecules which play an important role in regulation of gene expression. One of the most important type of small RNAs are microRNAs. MicroRNAs are conserved and function in RNA silencing and post-transcriptional regulation...
Categories:
Therapeutics & Diagnostics
Sono-dynamic nanoparticles for treatment of cancer
Sono-dynamic therapy (SDT) is anti-cancer therapy that utilizes deep tissue-penetrating therapeutic ultrasound (US) waves to activate a sonosensitizer, thereby locally generating reactive oxygen species (ROS) in the tumor microenvironment and triggering cancer cell apoptosis. SDT is localized and minimizes side...
Categories:
Therapeutics & Diagnostics
Sperm-induced cell-to-cell fusion as a male fertility diagnosis test
Approximately 15% of couples of reproductive age face fertility issues, with about a third attributed to male factors. Assisted Reproductive Techniques (ART), such as the conventional in vitro fertilization (IVF), and intracytoplasmic sperm injection (ICSI), are commonly employed to aid...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Stable broad-spectrum decoy antivirals
This broad-spectrum antiviral nanoparticle technology leverages artificial intelligence (AI) and synthetic biology to develop decoy receptors that neutralize viruses before they infect human cells. These nanoparticles are composed of synthetic long non-coding RNA (slncRNA) molecules, which self-assemble with virus-targeting receptor...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Synthetic living medicine for gut inflammation (Crohn’s disease) diagnosis and treatment
By combining advanced synthetic biology and microbiome engineering, this technology harnesses genetically modified bacteria to both diagnose and treat gut inflammation, such as Crohn’s disease and ulcerative colitis. These engineered bacteria are designed to detect specific biomarkers of inflammation (e.g.,...
Categories:
Therapeutics & Diagnostics
Targeted delivery of inhalation medicine using magnetic particles
The lungs can be described as a dense tree, where the airways resemble branches, ending with raspberry-like acinar sacs. The acinar sacs are made of alveoli, the basic respiratory units of the lungs. The alveolar lumen is composed of a...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Targeting bZIP transcription factors to restore cardiac function and treat heart failure
Cardiovascular disease is the leading cause of death globally, accounting for one in four deaths in the U.S. alone. Despite this burden, the development of novel cardiovascular drugs over the past two decades has been limited, with concerns over their...
Categories:
Therapeutics & Diagnostics
Targeting UBB+1 for treating Alzheimer’s disease
As human life-span increases, prevalence of Alzheimer’s disease is soaring, reaching plague-like numbers worldwide. Alzheimer’s disease is a debilitating disease characterized by toxic protein build up in the brain that inevitably leads to dementia and loss of independence of the...
Categories:
Therapeutics & Diagnostics
Therapeutic agents penetration into solid tumors
Solid tumors treatment is a significant challenge. Solid tumors present a complex microenvironment that severely restricts the penetration of therapeutic agents, leading to suboptimal therapeutic efficacy due to a. Dense Extracellular Matrix which creates a physical barrier b. High Interstitial...
Categories:
Therapeutics & Diagnostics
Topologies of synthetic gene circuit for optimal fold change activation
Genetic regulatory networks implemented in various synthetic gene circuits in living cells for purpose of sensing, computing, and actuating in fields of diagnostics, monitoring etc. Untight control of transcriptional regulatory networks applied on promoters, which are the basic transcriptional regulatory...
Categories:
FoodTech & Biotechnology|Therapeutics & Diagnostics
Toxin peptides for NMDAR inhibition and GABAB potentiation, for reducing neuronal excitability and excitotoxicity
NMDA-receptors (NMDARs) are a common downstream denominator for several neurodegenerative diseases, Alzheimer’s Diseases (AD) in particular, with the GluN2B-subtype being the primary culprit. Non-competitive NMDARs antagonists (FDA-approved memantine) may be used clinically to treat AD, but suffer from significant drawbacks...
Categories:
Therapeutics & Diagnostics
TSPO ligand to prevent traumatic brain damage
The present invention relates to heterocyclic compounds based on a quinazoline scaffold, which bind effectively to the mitochondrial translocator protein (TSPO) and counteract cell death processes. These novel TSPO ligands can be used for treating or preventing neurodegeneration including microglial...
Categories:
Therapeutics & Diagnostics
Tumor mutational burden from a single sample RNA-sequencing
Immunotherapy has revolutionized cancer therapy. Yet, many patients do not respond, thus making the search for biomarkers a critical need. One of the FDA-approved biomarkers is Tumor Mutational Burden (TMB), standing for the number of somatic mutations detected in the...
Categories:
AI & Data Science|Therapeutics & Diagnostics
Tumor suppression via ubiquitin ligase KPC1
NF-κB is a key transcriptional regulator involved in inflammation and cell proliferation, survival, and transformation. Several key steps in its activation are mediated by the ubiquitin (Ub) system. One uncharacterized step is limited proteasomal processing of the NF-κB1 precursor p105...
Categories:
Therapeutics & Diagnostics
Tumor-specific chemosensitivity assay for breast cancer
The incidence rates of breast cancer have been increasing worldwide for the past few decades. Advances in breast cancer detection techniques and treatment approaches are responsible for reduced mortality; however, even with newer drugs that induce a better response and...
Categories:
Therapeutics & Diagnostics
Ultrasensitive RNA and mRNA quantification using nanopores as biosensors
The ability to sense and digitally count individual RNA and mRNA biomarkers holds a great potential for early diagnosis of a wide range of diseases from cancer to infectious diseases, including the recent SARS-CoV-2. The ‘gold-standard’ method for RNA molecules...
Categories:
Medical Devices & Digital Health|Therapeutics & Diagnostics
Universal system for scalable expression and purification of proteins
There is a critical need for common technology for the robust production protein-based therapeutic drugs for vaccines and diagnostics, as well as for supporting alternative protein industry, including cultured meat and cultured milk. Despite the introduction of Insulin some four...
Categories:
FoodTech & Biotechnology|Therapeutics & Diagnostics
Usage of cannabinoids for skin repair and regeneration
Manipulating the activity of the endocannabinoid system (ECS) offers therapeutic potential for a multitude of pathological conditions affecting humans. ECS receptors such as cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2) have been found to be expressed in the...
Categories:
Therapeutics & Diagnostics
Using Bioactive fibrin matrix tissue engineering blood vessels
Tissue engineering holds enormous potential to replace or restore the function of damaged tissues. Nevertheless, functional vascular network must be generated to deliver blood quickly upon implantation. The invention is based on the clinically approved Fibrin gel (BAC2 and Thrombin)...
Categories:
FoodTech & Biotechnology|Therapeutics & Diagnostics
Insulin-dependent diabetes mellitus (IDDM) is a chronic inflammatory disease in which there is autoimmune-mediated organ-specific destruction of the insulin-producing beta cells in the pancreatic islets of Langerhans. These result in glucose homeostasis abnormalities and produce metabolic complications that are frequently...
Categories:
FoodTech & Biotechnology|Therapeutics & Diagnostics
Wearable stretchable microneedles-based platform
Microneedles devices to monitor materials in the interstitial fluid or inject materials to it are widely used for a range of medical conditions. Those are hollow microneedles as they need to pass fluids from and to the body. As such...
Categories:
Chemistry & Materials|Medical Devices & Digital Health|Therapeutics & Diagnostics
X-ray free imaging for adolescent scoliosis diagnosis
Adolescent Idiopathic Scoliosis (AIS) is a prevalent disease that currently requires radiographic imaging for accurate diagnosis and treatment planning. Much work has been done to identify and classify scoliosis using surface and topographic measurements, but current techniques rely on local...
Categories:
AI & Data Science|Medical Devices & Digital Health|Therapeutics & Diagnostics
